New study shows charged particles can kill cancer cells by clogging ‘waste treatment units’

According tomedia New Atlas, cancer has many tools to survive and develop, so there are many possibilities to stop the development of cancer. One such pathway focuses on “waste disposal units” of cells called lysosomes, which are particularly vulnerable to cancer cells compared to healthy cells. South Korean scientists have discovered that by carefully mixing charged nanoparticles, they can deliver deadly blows to cancer cells.

New study shows charged particles can kill cancer cells by clogging 'waste treatment units'

Lysosomes are tiny sacs filled with enzymes and acids that degrade unwanted parts of the cell and then recycle or dump it out of the cell wall, just as they do when they bring garbage to the side of the road. Recent studies have shown that lysosomes may play a role in Alzheimer’s disease, where dysfunctional disposal systems can lead to the accumulation of toxic proteins in the brain.

Scientists at the Korea Institute of Basic Sciences are working on dysfunctional lysosomes because the release of garbage from damaged lysosomes inside cells can cause the cells to die, which is clearly a good thing when cancer cells are involved. One thing that benefits the team is that the lysosomes of cancer cells are more likely to be damaged than healthy cells. The trouble is to propose a treatment that only targets the former, leaving the latter intact.

The researchers believe they have found a way to achieve this goal, involving a fine mix of negatively charged and positively charged nanoparticles. These are selectively clustered on the surface of cancer cells and then converted into nanoparticle crystals inside the lysosome, causing them to swell, spoil and eventually die.

Bartosz A. Grzybowski, co-author of the study, said: “In this work, we used a deregulated cancer cell waste management system to act as a ‘nanoscale assembly line’ to build high-quality nanoparticle crystals that can destroy very lysozymes. reactors, so that they grow first. “

New study shows charged particles can kill cancer cells by clogging 'waste treatment units'

The team experimented with different formulations of the new treatment and found that nanoparticles with 80 percent positive and 20 percent negatively charged ligands were the best for cancer cells. The team also believes that pH sensitivity to partially charged ligands is key to cancer cell selectivity. This was determined by experiments on multiple cancer cell types, and the team’s nanoparticles have been shown to be effective for all cancer cells.

Magdalena Borkowska, lead author of the study, added: “Our conclusions are based on a comparison of 13 different sarcoma, melanoma, breast and lung cancer cell lines with four non-cancer cell types. Nanoparticles are effective in all 13 cancer cells without harming non-cancer cells. “The team plans to study in the future whether this hybrid charge strategy can be effective against tumors in animal models.

The study was published in the journal Nature Nanotechnology.