Type A blood group more susceptible to the new coronavirus? Expert: Scientific basis is not yet sufficient

On March 18th an article entitled “New Coronary Pneumonia Latest Research: Relative Susceptibility to Type A Blood” was painted. The latest research shows of 8 units, including Southern University of Science and Technology, Shanghai Jiaotong University, Wuhan Zhongnan Hospital and Wuhan Jinyintan Hospital, show that there is a correlation between A, B, O, AB blood type and susceptibility to new coronary pneumonia. This is also the first study in this field. The study found that Type O blood is relatively less susceptible to new coronary pneumonia, the risk is lower, and type A blood is relatively susceptible to new coronary pneumonia, the risk is higher.

The research paper Relationship Sa the ABO The Blood and the COVID-19 Weeks was published on March 17 local time on the pre-printed platform medRxiv and has not yet been peer-reviewed.

Type A blood group more susceptible to the new coronavirus? Expert: Scientific basis is not yet sufficient

“The study is based on the results of clinical epidemiological statistics, whether it is scientific, still need to carry out a larger investigation, especially to carry out the relevant O-blood population natural antiviral mechanism research, before confirming.” Zhao Wei, director of the third-level biosecurity laboratory at Southern Medical University, told Science and Technology Daily.

Zhao Wei said that the new coronavirus is currently mainly infected with the respiratory system, the level of viral emia is relatively low, the duration is relatively short, the extent of blood type can affect the progression of the disease, need to be more detailed research, in order to clarify the significance of prevention and control work.

“The blood type is commonly referred to as the ABO blood type, which is divided into four blood types based on the presence of antigen A and antigen B on the red blood cell membrane. People with different blood types contain different antibodies in their serum, but not antibodies against their own erythema antigens. If type A blood contains anti-B antibodies, type B blood contains anti-A antibodies. Red blood cells themselves lose the ability to divide and do not contain the nucleic acids and protein synthesis systems needed during the virus replication process, making them less susceptible to the virus. Zhao Wei explained.

The director of the hepatology center of Beijing Ditan Hospital, affiliated with Capital Medical University, also believes that to judge whether different blood types (in this case, ABO blood type system) are susceptible to a disease, must be in the same exposure, that is, the same exposure to the source of infection, exposure time is the same, and there are no antibodies or other protective measures against the disease to compare the differences. Such as HIV, the virus in the invasion of the human body, must have CCR5 of the chemokine receptor, if the receptor is lacking, the virus is not infected.

“Is the phenomenon reported at hand a companion, or is it really relevant?” Further research is needed to confirm this. Yu stressed that more data and research evidence are needed to prove it.

In the report, the researchers also found that staff in type O blood-type hospitals had a lower chance of being infected than non-O-type hospital staff.

In this regard, Zhao Wei said, from the text, anti-A antibody is the main discussion of blood type-related mechanism factors. But there are anti-A antibodies in both type B and Type O blood, what is the reason for the susceptibility difference between the two blood types? There are no anti-A antibodies to both blood type A and AB blood, what is the reason for the difference in susceptibility between the two? Further research is needed. For example, it is possible to further carry out differences in the level of viruses in the blood stage of viral emias in different blood types, to study the possibility of infected cells in the blood, or to conduct anti-A antibodies to suppress neo-coronavirus infection experiments to directly answer the above questions.

Zhao Wei believes that this study is still an early study, can not draw a positive conclusion, the impact of prevention and control work is difficult to carry out scientific assessment.