German scientists decode the main protease structure of the new coronavirus

A new issue of the U.S. journal Science published a paper by German researchers saying they decoded the three-dimensional structure of the main protease of the new coronavirus and developed a compound that blocks the protease’s function, which is expected to be used to develop drugs that effectively suppress the new coronavirus.

Researchers at the University of Luebeck in Germany and others say a protease called Mpro is the main protease in the new coronavirus, which plays a key role in the virus replication process. They used high-intensity X-rays to decode the three-dimensional structure of this protease.

On this basis, the researchers tested the effect of a series of compounds on this protease, and found that the compound code 13b effectively blocked the function of the protease. The researchers also tested the compound in mice, which showed no adverse reactions.

Researchers say it is possible to build on the compound to further develop drugs that can effectively suppress the new coronavirus, which could be used directly to the lungs of patients with new coronary pneumonia.