On March 20, local time, a research paper was published on the pre-printplatform SSRN, which explores the clinical characteristics and results of co-combined COVID-19 in diabetic patients. The study found that the mortality rate of diabetics after infection with new crowns was higher than that of non-diabetic patients under the same conditions, and that they were more likely to develop multiple organ problems, secondary infections, and poorer prognosis.
The paper was entitled “Diabetic Patients with COVID-19, Characterizs and Outcome: A Two-Centre, Retrospective, Case Control Study”, The members of the thesis team are from Wuhan University People’s Hospital, The University of Hong Kong Li Ka-shing School of Medicine, etc.
The retrospective study of double-center case control was conducted at Wuhan University People’s Hospital and Wuhan University Zhongnan Hospital. The study selected 79 patients with diabetic COVID-19 from January 1 to February 25. The researchers randomly selected a new diabetic-free coronavirus infection for each diabetic with a matching age and sex. The data collected includedemographic and clinical characteristics, laboratory parameters, outcomes, clinical processes, and treatment.
Of the 823 COVID-19 confirmed patients, 79 (9.6%) were diabetics, according to the paper. The median age is 66 (IQR, 56.0-73.3). The mortality rates for diabetics and matching non-diabetic patients were 35.4% and 20.3%, respectively.
People with new coronaviruses are more likely to have potential comorbidities, including high blood pressure and cardiovascular disease. At the same time, diabetics with the new coronavirus are prone to complications, including ARDS (acute respiratory distress) (39.2 vs 20.3%), acute heart injury (46.8% vs 22.8%), AKI (acute kidney injury) (17.7% vs 6.3%), secondary infection (43.0% vs vs. 21.5%) and shock (35.4 % vs 20.3%).
Studies have shown that non-survivors of new coronavirus infection are older (74.5 vs 63 years old) and more likely to have underlying diseases. Non-survivors reported higher random average blood sugar during hospitalization (13.5 vs 7.3 mmol / L).
Compared to diabetes survivors, complications, including ARDS, were more frequent (100.0% vs 5.9%), acute heart damage (96.4% vs 19.6%), AKI (50.0% vs 0), secondary infections (75.0% vs 25.5%) and shock (96.4% vs vs. 2.0%) found in non-survivors.
According to the researchers, the coVID-19 mortality rate of diabetic patients is 35.4%, and diabetics are more likely to have multiple organ dysfunction, secondary infection and poor prognosis. Diabetes itself, combined with old age, other potential combinations, and poor blood sugar control during hospitalization, leads to a poor prognosis for COVID-19 in diabetics.