Stem cell technology rejuvenates human senescent cells

Scientists at Stanford University may have found a way to restore aging cells to a younger state,media reported. Scientists used adult cells to process mixed proteins from early embryonic development, which allowed many molecules with signs of aging to be removed. These cells are very similar to younger cells, and older animals regain muscle strength in their youth in mouse experiments.

Stem cell technology rejuvenates human senescent cells


Stem cells have an extraordinary ability to differentiate and can essentially differentiate into any other type of cell in the body. Not only is this important for the healthy development of embryos, but it also opens up a possible treatment for replenishing lost cells to repair organ and tissue damage.

Induced pluripotent stem cells (iPS cells) are an emerging treatment. The scientists first took samples of adult cells from the patient’s skin and exposed them to the so-called Yamanaka protein. This is actually a return to the cell clock in the embryonic state, where they are once again ready to become any special cells they need today.

But scientists involved in the new study want to know if the therapy could also be used for more general anti-aging purposes. To do this, the Stanford team experimented with cultured human cells and live mice.

The team started with human skin and vascular cells and used messenger RNA to force them to express six reprogramming factors. A few days later, they compared untreated cells from the nucleus of elderly people with untreated cells from young people.

As a result, the researchers found that after four days of treatment, the gene expression of geriatric cells was more similar to that of younger cells. By comparing methyl groups of marked cell age, treated older cells were on average 1.5 to 3.5 years younger than untreated older cells, and vascular cells were up to 7.5 years younger.

In other trials, the researchers found that various other characteristics of aging also showed significant recovery, including metabolism, nutritional awareness, and waste removal. Cartilage cells in patients with osteoarthritis also showed lower inflammation and higher cell division after treatment.

The mouse experiment has also proved very promising. The team extracted muscle stem cells from older mice, treated them and transplanted them back into animals. As a result, the researchers found that the treated elderly mice regained most of their muscle strength in the younger mice.

The researchers hope to one day restart the entire tissue, but until then they have a lot of work to do to make sure the treatment is safe and effective for humans.

The study was published in Nature Communications.