New crown impairment male reproductive function first clinical evidence: significant changes in sex hormone levels

Sex hormone levels provide the first clinical evidence that the new coronavirus affects the male glands. The researchers again cautioned against the reproductive function of male patients of childbearing age. Zhang Ming, an associate professor at the Center for Reproductive Medicine at Zhongnan Hospital, Wuhan University, and others recently uploaded a paper entitled “A Single Center Study on the Effect of New Coronary Infection on the Function of the Male Sex Glands” (Effect of SARS-CoV-2 infection) on the pre-printed website MedRxiv (not subject to peer review and publication) En male gonadal function: A single center-based.

The study compared 81 new crown patients of childbearing age with 100 healthy men of similar age and found that serum provocatone serotonin (LH) and prolactin levels increased significantly, while testosterone had a significantly lower ratio of LH to follicle stimulator.

LH is a glycoprotein gonadotropin secreted by adenophac cells that promotes the conversion of cholesterol into sex hormones within gonad cells. The authors argue that although semen parameters are a direct reflection of reproductive gland function, the change in these indicators also provides the first indirect clinical evidence for new coronary attacks on testicular function.

Disease-causing targets

It is well known that the target point of the new coronavirus attack cell is the receptor angiotensin conversion enzyme II referred to as ACE2. This target doesn’t just appear in the lungs.

In mid-February, Nanjing Medical University affiliated Suzhou Hospital urology department Yu Caibin and other concerns about a number of new coronapatient patients with abnormal kidney function and even damage. While verifying that the new crown attack targets are highly expressed in the kidneys, they also accidentally found that the protein and mRNA expression of these targets in the testes are almost the highest in the human body, including mesoplasmic cells and vasectomy cells.

In late February, two researchers at the National Institutes of Health (NIH) also pointed out that the targets of the new coronavirus were mainly concentrated in the testes of sperm cells, meenda cells and supporting cells.

In theory, any cell with such a target is vulnerable to new coronaviruses. Moreover, because the blood testicular barrier cannot completely isolate the virus, the virus in the blood mainly attacks the testicles, compared to bacterial infections that usually attack the appendicitis and parades.

Zika, Ebola, Marburg virus, etc. have been found in male testes and semen and cause sexual transmission. HIV and mumps can also induce testicular itisis and even infertility.

SARS, which has the same target as the new crown, has been found to cause testicularitis.

Overall, the researchers speculate that new coronary infections may inhibit the function of cells associated with reproduction, which can lead to the failure of sperm.

However, this speculation has not been clinically validated.

81 patients

The team at the Center for Reproductive Medicine at Zhongnan Hospital, Wuhan University, conducted a retrospective study of serum samples from 81 male new crown patients. They were admitted to Wuhan’s Raytheon Mountain Hospital on March 5 and were aged between 20 and 54 (median 38).

Of the 81 cases, 2 were “light” patients with no positive changes in the chest, 70 were diagnosed as “normal”, i.e. with fever, cough and other common respiratory infection symptoms, chest positive changes, 7 cases were “severe”, i.e. with a certain degree of breathing difficulties and other symptoms, and the remaining 2 cases were “very serious” with respiratory failure, Shock or multiple organ dysfunction.

New crown impairment male reproductive function first clinical evidence: significant changes in sex hormone levels

Basic data on 81 male new crown patients

A total of 31 cases showed elevated serum alanine transaminase (ALT) and/or serum aspertysinine transaminase (AST), indicating impaired liver function

The control group was a random sample of 100 healthy men of similar age and normal reproductive function.

Hormones tested include testosterone (T), estradiol (E2), progesterone (P), progesterone (P), progesterone (PRL), progesterone (LH), follicle stimulator (FSH), and anti-Miaole tube hormone (AMH).

Changes in sex hormone levels

Compared to the control group, the levels of progesterone and prolactin were significantly higher in the new crown patients, while the ratio of testosterone and follicle stimulator to progesterone was significantly reduced.

The researchers believe that although there was no significant change in testosterone levels, there was a subtle negative feedback mechanism for testosterone and LH. In the early stages of decreased sexual function, damage to testosterone production may stimulate LH release, allowing testosterone levels to be temporarily maintained.

As a result, the proportion of sex hormones, such as testosterone/LH, better reflects male reproductive gland function.

New crown impairment male reproductive function first clinical evidence: significant changes in sex hormone levels

Sex hormone levels in experimental and control groups

Increased levels of prolactin may lead to pituitary inhibition and reduced gonadotropin.

There was no significant change in FSH levels of hormone suppression by supporting cells, suggesting that the effect of the new coronavirus on supporting cells may be smaller than that of intersomeal cells.

Taken together, the authors argue that elevated LH and lower testosterone/LH ratios may be caused by testicular dysfunction, such as intersomeal cell damage.