In the history of mankind, to overcome aging is a worldwide problem, in ancient times, the emperors are obsessed with the art of long-term life, and in the medical highly developed today, return to the old child, long-term life may have a ray of hope! In a new study published in Nature Communications, researchers at Stanford University say that aging human cells return to a youthful state after a brief induction of a group of proteins involved in embryonic development.
The study found that if the muscle stem cells in the aging mice were repaired and then re-transplanted back into the mice, the aging mice were able to regain their youthful vitality and the muscle strength of the young mice!
The protein is called the Yamanaka factor, which scientists often use to convert it into annual cells to induce pluripotent stem cells.
In laboratory dishes, researchers successfully induced senescent cells to express the Yamanaka factor briefly, and the results showed that many of the molecular characteristics of aging cells have been reversed, even from younger cells.
By repeatedly exposing adult cells to a group of proteins vital to early embryonic development, the experimenters produced iPS cells. During this time, rna information, encoded in the Yamanaka protein, is injected daily in adult cells.
Over time, these proteins reverse the fate of adult cells and restore their youthful status.
Researchers at the Salk Institute of Biology found several years ago that the Expression of Yamanaka factors in mice with premature aging increased their lifespan by about 20 percent, but it is not known whether they would be suitable for humans.
The researchers compared differences in gene expression patterns between treated older cells, control cells, and young cells. They found that if older people’s cells were treated with reprogramming factors, they showed signs of reversal of youth after just four days.
In addition, when analyzing the chemical labels associated with aging, it was found that after treatment the cells were on average about 1.5 to 3.5 years younger than normal cells.
Currently, researchers are optimizing the reprogrammed protein combinations needed to revitalize human cells and testtheming them rigorously to ensure safety.