Recently, according to media reports, a new study published in the leading American journal Cell by a team led by the Chinese Academy of Sciences shows that more than one-half of aging cells and a quarter of the aging genes can be reversed when the diet is controlled at seven full.
Using rodent rats, the researchers mapped the first multi-organ monocellular transcriptome spree for mammalian aging and dieting based on high-throughput monocytosis and mono-core transcription techniques, and systematically assessed the effects of aging and dieting on different types of tissue cells in the body.
In the study, the researchers divided the participants into three groups: the young free-eating group, the old-age eating group, and the old-age diet group. The rats were then given “seven-point satiety” (70 percent of their calorie intake) from the medium age and continued to diet for nine months. This is the equivalent of a human diet from about 40-45 years old to the age of 70, the researchers said.
The researchers found that the “seven-point” intervention reduced the signs of aging at the cellular, tissue and molecular levels and increased their lifespan. In addition, an analysis of transcription groups of more than 200,000 single-cell and nuclei obtained from nine tissues showed that the tissues tested had a change in the composition of the type of cells associated with aging, and that more than half of those changes could be inhibited by diet.
Increased stress on multi-tissue immune inflammation is a hallmark of aging, and dieting can effectively reverse the accumulation of pro-inflammatory cells in aging tissue, the researchers said. It has also been found that aging causes the Ybx1 gene to be less expressive in a variety of cell types, and dieting can reverse this change in more than 20 cell types.
The researchers note that for the first time, the study systematically analyzes the laws of cellular and molecular changes in the body’s aging at the multi-organ and multi-tissue levels, providing a new biological marker for early warning of aging.
At the same time, it also reveals the important role of immune regulation system in the process of dieting intervention in aging, and lays a theoretical foundation for further developing the intervention strategies of aging and related diseases, which is of great value in the scientific response to aging.