The brain slowly becomes silly, behind the scenes, “the mafia” is trans fatty acids.

Eating foods rich in trans fatty acids increases the risk of dementia such as Alzheimer’s disease, new research has found. Recently, the world’s first new Alzheimer’s disease drug in 17 years was approved to the market, the news of strong screen, public concern about Alzheimer’s disease has increased.


Alzheimer’s disease is one of the most common types of dementia in old age, and clinical manifestations such as cognitive decline and gradual memory loss have changed many people. However, you may not know that too much fat in your life can also increase the risk of Alzheimer’s disease and other dementias.

Japanese researchers recently published a new study in the Journal of Neurology of the American Academy of Neurology, finding that eating industrial foods rich in trans fatty acids increases the risk of dementia such as Alzheimer’s disease.

 Poor eating habits and increased risk of old age dementia

Fatty acids are the simplest kind of lipids, which can be divided into saturated fatty acids and unsaturated fatty acids according to the molecular structure. Among them, unsaturated fatty acids contain trans non-conjugate double bond structure, it is called trans fatty acids.

Dementia is a “big family” that includes vascular dementia, all-cause dementia and mixed-type dementia, in addition to the most well-known Alzheimer’s disease. Beginning in 2002, Japanese researchers followed 1,628 Japanese community residents aged 60 and over with dementia for 10 years, measuring levels of trans fatty acids in the participants’ serum and using models to assess the risk of all-cause dementia, Alzheimer’s and vascular dementia in the population.

The researchers found that levels of trans fatty acids in the human serum were associated with all-cause dementia and Alzheimer’s disease, but were not significantly associated with the risk of vascular dementia.

During the follow-up, 377 participants developed certain types of dementia, including 247 Alzheimer’s patients and 102 vascular dementia patients. When the researchers adjusted the traditional dementia risk factors, the higher serum trans fatty acid levels in the body were significantly associated with an increased risk of all-cause dementia in the population and an increased risk of Alzheimer’s disease, and when dietary factors were adjusted, such as total calorie intake and saturation, unsaturated fatty acid intake, these associations were still significant.

The researchers concluded that higher levels of trans fatty acids in the serum may be a risk factor for all-cause dementia and Alzheimer’s disease.

In fact, the association between trans fatty acids and dementia has long been the focus of researchers. As early as the 1990s, researchers found that people who had poor eating habits in their teens had an increased proportion of People with Alzheimer’s disease in old age, science and technology daily reporters learned. A long-term follow-up study of 2,560 people over the age of 65 living in suburban Chicago found that cognitive function declined more quickly among those who ate large amounts of trans fatty acids in older adults.

So what are the bright spots of this new study?

“There are many risk factors for dementia. In alzheimer’s disease, for example, the known risk factors for the disease include genetic and environmental factors. Environmental factors include smoking, obesity, diabetes, physical inactivity, depression and so on. These factors may be interrelated and useful. Li Peng, a health science expert at the Beijing Municipal Health Commission and deputy director of the Geriatrics Department of Beijing Stable Hospital at Capital Medical University, said that when studying the effects of a single factor on the condition, other risk factors for the condition become “mixed” factors that can interfere with the results. The study removed the “mixed” factors of traditional dementia risk and further confirmed a link between trans fatty acid intake and the onset of dementia in a similar way to controlling variables. “This is the innovation of the study. Li Peng said.

Entering the blood to participate in metabolism is the “co-help” of a variety of diseases

Why do trans fatty acids make the brain slowly silly?

“This mechanism is not yet fully understood, but the academic community has put forward a variety of hypotheses about the mechanism of trans fatty acids that cause Alzheimer’s disease. Trans fatty acids can increase the deposition of A-beta protein in the brain, causing oxidative damage of nerve cells in the brain, etc. Li Peng said.

Old age spot is the main neuropathological characteristic of Alzheimer’s disease, and A beta protein is the main component of the old spot. Studies have shown that trans fatty acids increase a beta protein levels, increase total cholesterol levels, and accelerate arteriosclerosis in the brain. Studies have also shown that trans fatty acids inhibit cell proliferation and cause oxidative damage to nerve cells by reducing the activity of specific enzymes. The oxidation damage of cells is often related to aging and functional degradation.

In addition to dementia, trans fatty acids are also “complicit” in many diseases. “Previous studies have shown that excessive intake of trans fatty acids may increase the risk of cardiovascular disease, diabetes, obesity and other diseases,” Dr. Meng Fanqiang, deputy director of gastroenterology at The China-Japan Friendship Hospital, told Science and Technology Daily. “

Trans fatty acids increase ldl cholesterol levels and lower high-density cholesterol levels, according to the World Health Organization’s official website. High-density cholesterol cleans the arteries and transports them to the liver, which is then secreted into the bile, and LOW-density cholesterol is recognized by the academic community as one of the biomarkers of cardiovascular disease risk. If you eat foods rich in trans fatty acids, you have a 21 percent increased risk of heart disease and a 28 percent increased risk of mortality. In addition, there is evidence that trans fatty acids can increase inflammation and endothelial dysfunction.

“Trans fatty acids enter the bloodstream and participate in body metabolism. Therefore, blood and metabolic-related diseases should be alert to the possible adverse effects of trans fatty acids. Meng Fanqiang pointed out that the presence of trans fatty acids will increase the viscosity of the human blood, increase thrombosis is likely, because trans fatty acids are easy to deposit in the body, resulting in abdominal obesity, and obesity can cause a variety of diseases.

Li Peng told reporters that pregnant or lactating women intake of trans fatty acids, will be passed through the placenta or breast milk to the fetus, affecting the growth and development of the fetus and baby. Teenagers who ingest too much can also have adverse effects on the development of the central nervous system.

  No health benefits, mainly from processed foods

“Trans fatty acids do not have any known health benefits. “The World Health Organization’s official website says.

Since trans fatty acids “sin” more and more harmful, how to avoid excessive intake in daily life?

The first problem to be clarified is the source of trans fatty acids. “Some natural foods also contain trans fatty acids, but their main source comes from processed foods. Meng Fanqiang said that naturally occurring trans fatty acids come from ruminants such as cattle and sheep. After intake of feed, the ruminant animal sits a biochemical reaction in the stomach to produce trans fatty acids, which are absorbed and then entered into the animalbody. Therefore, beef and mutton, milk, dairy fats will contain a small amount of trans fatty acids.

Studies suggest that trans fatty acids in processed foods are produced by hydrogenation of oil, making liquid sin-state form a “partially hydrogenated” oil production process. Hydrogenated vegetable oil is the main source of trans fatty acids. Hydrogenated oils are more stable, non-metamorphic, and can maintain solid shape at room temperature, making processed foods more “typed” and easier to transport and store. In addition, hydrogenated grease can also increase the taste and taste of food, firmly grasp the consumer’s stomach. All foods containing “hydrogenated oil” or fried with “hydrogenated oil” will contain trans fatty acids, such as margarine, margarine and related products, baked and fried foods using “hydrogenated oil”.

According to statistics, about 540,000 deaths worldwide each year are related to the intake of industrially produced trans fatty acids. The average global trans fat intake in 2010 accounted for 1.4% of total energy intake, ranging from 0.2% to 6.5% between countries, and 0.13 to 4.3 grams of a 2,000-calorie diet per day. North America, Latin America and North Africa/Middle East have the highest intake, and young people generally have higher intake, according to the small amount of information available.

Based on a total energy intake of 2,000 calories per day, the World Health Organization recommends limiting the daily intake of trans fatty acids to 2.2 grams. According to China’s food safety requirements, food packaging should be labeled trans fatty acid content, the public can do reference when buying.

“People should eat as little trans fatty acids as possible in their daily lives, and it is important to maintain a healthy diet and habits. Meng Fanqiang expressed the hope that the harm caused by trans fatty acids in the future will be well prevented and controlled. (Intern reporter Yu Ziyue)

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