With its many important chemical properties and the substance “water” in which multiple chemical reactions can be allowed to occur, it has been the first indicator of the scientific community’s search for the possibility of extraterrestrial life for many years, while single-celled organisms such as bacteria that live in extreme environments on Earth have been used as a reference for the possible appearance of extraterrestrial life. But a new study shows that even with water, the environment in which living things can live is still extreme. In Ethiopia, there is a special geomorphological area called Danakil Depression, because it is the junction of three separate plates, so the formation is particularly thin, but also has the heat from the ground, the heat, the rye, etc., so that the pool here is not only very high temperature, but also high in salt weight, acidity. Here scientists have found no signs of biological survival, suggesting that liquid water alone is not enough. Danakil Depression also provides a valuable laboratory for scientists to compare based on varying degrees of salinity and acidity — in pools with slightly low temperatures and low acidity, but high salinity, scientists have discovered new varieties they have never seen before. In addition to setting limits on tolerance of living things, Danakil Depression also demonstrated “false evidence” that requires special care. In pools where no living things exist, scientists have discovered tiny silicon spheres that resemble small cells under a microscope. If the probes going to other planets do not have special analytical equipment, which is analyzed by microscopic photographs alone, it could mislead scientists into thinking that this is evidence of the existence of living things. Of course, all this is based on carbon-based organisms, after all, carbon-based organisms are our most familiar species, and carbon chemistry diversity, so that it has a unique potential and plasticity among elements. But this does not preclude the possibility of developing other kinds of chemistry, even non-chemical-based organisms, in other stars.