The most common symptoms of the new coronavirus include fever, cough, cough and shortness of breath, while other possible symptoms include loss of taste or smell, sore throat, headache, muscle pain and chills,media BGR reported. There are also gastrointestinal symptoms, including diarrhea and vomiting. The U.S. Centers for Disease Control and Prevention (CDC) does not currently list them on the COVID-19 symptom list, but does mention that children may develop these symptoms. These gastrointestinal symptoms are unusual for respiratory diseases, but researchers have finally explained why this happens.
Scientists from the Hubrecht Institute in Utrecht, the Netherlands, the Erasmus University Medical Center in Rotterdam and Maastricht University in the Netherlands, have been able to grow an artificial intestine (an organism) from adult stem cells. The researchers found that the virus binds to intestinal epithelial cells by binding to ACE2 receptors that allow them to enter the lungs. They published their findings in the journal Science.
Once these cells are invaded, the virus can continue to replicate and increase in number, just like it does in the lungs. Also, when the body detects a pathogen, the whole thing begins to produce an immune response. “These organisms contain cells from the lining of the human gut, making them a convincing model for studying SARS-CoV-2 infections,” Hans Clevers of the Hubrecht Institute told SciTech Daily.
Gastrointestinal symptoms can occur in up to one-third of COVID-19 patients, the report said. There are concerns that the virus could be transmitted through the route. In addition, other studies have suggested that fecal aerosols in bathrooms may be transmitted to others.
Using electron microscopes, scientists were able to determine the presence of viruses in gastrointestinal cells and found that they replicate over time. The white area in the image above indicates that the new coronavirus is present in the organoplasmal cells and is colored blue and green.
The researchers found that viruses can enter cells regardless of the level of ACE2 receptors. Even cells with low ACE2 receptor levels can become hosts of virus replication. The researchers also used RNA sequencing to observe the reaction sofority of intestinal cells. They found that interferon-stimulating genes were activated after infection, or known to fight viral infections.
“The observations in this study provide clear evidence that SARS-CoV-2 can reproduce in cells in the gastrointestinal tract,” said lead author Bart Haagmans. “However, we do not yet know whether SARS-CoV-2 in the intestines of PATIENTs with COVID-19 plays an important role in transmission. Our results suggest that we should study this possibility more closely. “