New research has found that the new coronavirus SARS-CoV-2 may be the result of the recombination of pangolin coronavirus with bat coronavirus. Researchers from South China Agricultural University and Guangzhou Zoo published the research paper in Nature as a correspondent.
On 7 May, researchers from South China Agricultural University and Guangzhou Zoo, together as a correspondent, published a research paper on “Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins” in Nature. The results suggest that the new coronavirus SARS-CoV-2 may be the result of the recombination of pangolin-CoV-like virus with the bat-CoV-RaTG13 virus.
If the wildlife trade is not effectively controlled, the newly discovered coronavirus in trafficked mammals could pose a threat to public health, the researchers said.
The paper says the new coronavirus SARS-CoV-2 has a high sequence homologousity with SARS-CoV and bat coronavirus RaTG13. Although bats may be hosts of various coronaviruses, it is not clear whether SARS-CoV-2 has other hosts.
The study isolated a coronavirus from a Malay pangolin, with the E, M, N and S genes and SARS-CoV-2 with amino acid homologousness of 100%, 98.6%, 97.8% and 90.7%, respectively. In particular, the receptor binding domain within the Pansamacovirus S protein is almost identical to the receptor binding domain of SARS-CoV-2, with only one non-critical amino acid difference.
Studies have shown that 17 of the 25 Malay pangolins analysed have detected pangolin coronavirus. Infected pangolins show edgtosis and histology changes, and circulating antibodies to pangolin coronavirus react with SARS-CoV-2 S-proteins. A highly correlated coronavirus with SARS-CoV-2 was isolated from the pangolin, indicating that they may be the intermediate host of SARS-CoV-2.
The origin of the new coronavirus has been the focus of scientific research, but the origin of the new coronavirus conspiracy theory – the new coronavirus is artificial manipulation or synthesis of the argument is very much on the rise. On 21 April, a WHO spokesman rejected the conspiracy theory of the origin of the new coronavirus, and on 23 April WHO, through its daily outbreak report, reiterated that all known evidence suggests that the new coronavirus originated in animals in nature, not that it was artificially manipulated or synthesized by laboratories.
WHO reported that after wuhan reported cases of new coronavirus infection in humans in December 2019, the whole genome sequence of the new coronavirus was published and shared from 11 to 12 January. Since then, the whole genome sequence of viruses from early infection cases and the viral genome-wide sequences obtained elsewhere in the world have shown that the evolution of the new coronavirus can be traced back to bat populations.