To date, tens of thousands of new crown patients have been clinically rehabilitated and discharged from hospital, but some discharged patients have re-tested positive for SARS-CoV-2 nucleic acid, which has raised concerns about “Fuyang”. On May 22, local time, the Journal of the American Medical Association (JAMA), an international authoritative medical journal, published a study entitled Coronavirus Disease 2019 Test Results After Recovery Clinical and Hospital Hospital PatientS in China, focusing on nucleic acid testing after discharge from the hospital.
Although there have been case studies on “Fuyang”, the systematic study of the overall prognosis of COVID-19 patients who meet the discharge criteria has not been reported. The research team came from hunan Normal University’s School of Life Sciences, the Center for Disease Control and Prevention in Yandi City, and the Infection Department of Xiangya II Hospital, Central South University.
Previously, two new crown patients in Hunan Province were discharged from the hospital and developed symptoms, and nucleic acid test positive, and was admitted to hospital. After that, the researchers collected nasopharyngeal and swab samples from 58 new crown patients who met the discharge criteria in Hunan Province before February 27 to assess the durability of the potential virus. In this study, cross-sectional studies were used and approved by the Institutional Review Committee of Hunan Normal University to obtain written and informed consent from all patients. This study follows the requirements of the Guidelines for Enhanced Epidemiological ObservationAl Studies (STROBE).
The researchers took samples of nasopharyngeal swabs and swabs from discharged patients and used real-time reverse-polymerase chain reaction (RT-PCR) to detect new coronavirus nucleic acids. They also collect demographic information and laboratory test results from electronic medical records.
Of the 60 discharge patients included in the study, the median age was 46.5 years (four-point difference, 33.5-58.5) and 26 were women (43.3%). A total of 10 patients (16.7%) of the RT-PCR test results were POSITIVE for SARS-CoV-2, of which 5 patients (8.3%) of the nasopharyngeal swab test positive, 6 patients (10.0%) of the swab positive test results, 1 nasopharyngeal swab and swab are positive. To remain anonymous, the 10 patients were identified by numbering, i.e. patients 1 to 10.
RT-PCR test results are SARS-CoV-2 positive patients, except for the patient 1 case and patient 2 occasional cough, there are no new coronary clinical symptoms, symptoms of 2 people are older than 70 years old, there are a variety of underlying diseases. Patient 2 coughed and coughed 5 days after discharge from the hospital, and on 27 March THE RT-PCR test was positive for SARS-CoV-2, with a virus discharge time of 56 days from the onset of the disease.
Patients took nasopharyngeal samples RT-PCR positive for SARS-CoV-2 after 3 weeks after discharge from hospital. Patient 4 donated plasma to patients with severe patients with antibodies (IgM) titration softos of 80 in the plasma on February 18, 2020. Nine health care workers were isolated after collecting patient 4 recovery-period plasma withinadequate personal protective equipment; however, all nine employees tested negative for the new coronanucleic acid and showed no symptoms for the next 2 months. After February 28, 2020, there was no new crown ratio in Hunan’s Yandi.
In this cross-sectional study, 10 of the 60 new crown patients discharged from the hospital tested positive for SARS-CoV-2 for 4 to 24 days after discharge. Since discharged patients have home isolation instructions and local cases are rare, the researchers speculate that the positive results are persistent virus release, rather than reinfection.
As previous studies have shown that THE virus in the feces of PATIENTs with COVID-19 has been falling off longer, the results of this study show that six patients after discharge from the hospital continued to have the virus falling in the gastrointestinal tract, one of whom (patient 2) tested positive in both samples on March 27, and the virus fell off for 56 days from the onset of the disease. In this study, the threshold period value of an alme swabs was lower than the threshold period value of the nasopharyngeal swab. However, since infectious viruses have not yet been isolated from stool samples, it remains unclear whether there is fecal transmission.
The study was limited to a small number of discharged patients who tested positive for SARS-CoV-2. Further research is needed to use larger queues and isolate live viruses instead of RT-PCR tests to determine whether they are contagious and to provide a lesson for disease management that continues after discharge from hospital.
Given that this and previous studies have shown that new crown patients may still be positive for SARS-CoV-2 nucleic acid, it is important to provide appropriate personal protective equipment for medical personnel when collecting patient recovery plasma. At the same time, the clinical recovery of plasma from the recovery of patients whether there is a continuous release of the virus, and its effects may need to be assessed separately.
It is worth noting that the pathology study of a patient who died of a new crown, published on April 28th, provides a rare perspective on the issue. A patient who tested negative for three consecutive new coronanucleic acids and met the criteria for discharge died of a heart attack. The researchers carried out a pathology study of the remains and found that the lungs still had new coronaviruses by slicing the tissues of the lungs, liver, heart, intestines and skin.
The study was published in the authoritative journal Cell Research. The authors include the Third Military Medical University of the Chinese People’s Liberation Army and the University of Southern Medical University. The authors are Yu Xiuwu, a member of the Chinese Academy of Sciences and a professor at the Army Military Medical University, and Professor Liu Xindong of the Third Military Medical University of the People’s Liberation Army Chinese.