A new cancer treatment vaccine based on self-healing microcapsules has been developed to effectively activate the immune system and suppress tumor development, according to a new study published in Science Advances by a chinese research team, according tomedia.
As a treatment method of immunotherapy, cancer vaccine due to the body’s microenvironment and other adverse factors, can not play its maximum effectiveness, but because of the cancer vaccine treatment potential, researchers have been constantly trying to improve and research new methods to achieve the desired results, but they are not satisfactory.
The research team, led by Professor Ma Guangandand and Professor Wei Wei from the Institute of Process Engineering of the Chinese Academy of Sciences, has designed and manufactured a variety of cancer vaccines in previous work. These vaccines have been shown to be effective in different tumor models, such as lymphoma, melanoma and breast cancer.
“However, due to certain limitations, researchers were forced to improve early cancer vaccines, ” said Professor Ma. For example, poor immune microenvironments, complex preparation processes and the need for frequent vaccinations have seriously affected vaccine performance. Therefore, we have designed a new type of high-efficiency cancer vaccine preparation based on microcapsules. “
This study represents the first time that researchers have used self-healing microcapsules with post-encapsulation, multiple loading, and effective regulation of immune microenvironmentins in tumor vaccines. After vaccination, these microcapsules can form a good immune microenvironment in situ, where antigens release power, absorb cellular behavior and acidic environments in a coordinated manner.
“Because of the synergy, the vaccine has succeeded in improving the utilization of antigens, improving antigen presentation and activating antigen submission cells,” Professor Wei said. Therefore, the use of different types of antigens in different tumor models can achieve effective T-cell reaction, effective suppression of tumors, and anti-metastasis and prevention of postoperative recurrence. “
In addition, the researchers verified the availability of new vaccine platforms used in the new antigen vaccine, which is consistent with precision medicine. Due to the simple post-encapsulation process, clinicians are able to prepare new antigen preparations at any time.