Study finds short rides can drive ‘death marker protein’ to refresh worn muscles

Exercise is an important part of a healthy lifestyle, and this view has become the consensus of many people. However, the positive effects of physical exercise on the human body, there are still many continuous findings. A new study by the University of Copenhagen in conjunction with the University of Sydney suggests that healthy muscles are not only the basis for strength and physical activity, but also play an important role in regulating metabolism. The researchers delved into muscle maintenance mechanisms and found that timely short rides also helped increase the activity of the “death marker protein.”

Study finds short rides can drive 'death marker protein' to refresh worn muscles

Infographic (from: Giant Bicycles)

A team of scientists from the University of Copenhagen and the University of Sydney has studied the mechanism sephyllbes of a protein called Ubiquitin.

Previous studies have emphasized that this protein can play an important role like a ‘vacuum cleaner’, marking defective proteins for destruction and replacing them with a functional new version.

Both moderate exercise and fasting can help strengthen the process to keep the body healthy and functioning properly, but new research presents new evidence that even short physical activity can have a positive impact.

The team conducted blood tests and muscle biopsies to check healthy men for ‘ubiquitin’ changes before, during, and after a high-intensity exercise.

It was found that about 10 minutes of hard cycling training could lead to a significant increase in ‘ubiquitin’ activity, which in turn enhanced the removal of wear and damaged proteins.

Professor Erik Richter, of the University of Copenhagen, explains: “Muscles can remove worn proteins in a variety of ways, and the ‘death marker’ of ‘ubiquity’ is one of them.

It is a protein in itself that binds to the amino acid lysine on a worn-out protein and then transports the protein to a protease (a devouring protein) and then spits out the amino acid structure.

These amino acids can be reused to synthesize new proteins, so “ubiquitin” helps the body’s proteins to circulate sustainably.

Maintaining healthy muscles is important not only for strength and physical activity, the researchers note. And because it stores a lot of carbohydrates, it can also play a key role in regulating metabolism.

In addition, these findings deepen our understanding of “how muscle contractions in rapid exercise initiate this protein removal process.”

Details of the study have been published in the recently published journal FASEB, originally titled

Quantification of Exercise-Regulated Ubiquitin Signaling in Human Skeletal Muscles Protein Pad Cross Talk via NEDDylation