Study finds long-term negative thinking more likely to develop Alzheimer’s

Between, bereavement? Bereavement, is “the world is not worth” the view of the world, is “Ge You lying” of the saucy, is “Ma man Bo Jack” negative. Despite some belief that bereavement culture is a reverse chicken soup, a new study from University College London suggests that being in a “lost” state for a long time can lead to cognitive decline and a more likely risk of Alzheimer’s disease. In short – too sad, too silly.

Too “lost” is prone to Alzheimer’s

Alzheimer’s disease (Alzheimer disease, AD), commonly known as Alzheimer’s disease, is a degenerative neurological disease.

Alzheimer’s disease is mainly associated with two substances – beta amyloid and tau protein, which can lead to memory loss and even deterioration due to the accumulation of amyloid proteins in the brain and the excessive phosphorication of tau proteins.

Although previous studies have suggested that anxiety, depression and other emotions are “risk factors” for Alzheimer’s disease, the risk of developing these emotions is independently considered.

Researchers at University College London believe that these negative psychological risks also lie in their frequency mechanism, repetitive negative thinking (Negative Repetitive Thinking, RNT).

The findings are now published in the alzheimer’s and Dementia journal, entitled “Twere negative thinking is is ed with amyloid, tau, and cognitive decline”.

Study finds long-term negative thinking more likely to develop Alzheimer's

Photo credit from Alzheimer’s and Dementia¬†

Over a two-year period, researchers conducted negative emotional studies of more than 350 middle-aged and older people over the age of 55, asking questions, questionnaires, and other examples to see if the subjects had RNT thinking patterns and whether there were negative emotions such as anxiety and depression, and focused on those with repetitive negative thinking.

In addition, the researchers performed amyloid positron and tau-PET scans on 113 subjects, and 68 people were scanned for IMAP-cohort amyloid-PET to assess the deposition of tau protein and amyloid protein.

It’s not over yet!

The researchers followed up for four years and found that middle-aged and older adults who had long been in persistent negative thinking had more tau and amyloid deposits in their brains and showed worse cognitive abilities, which was one of the early signs of Alzheimer’s disease.

Don’t understand? (See figure)

Study finds long-term negative thinking more likely to develop Alzheimer's

The higher the RNT number, the longer the repetitive negative thinking

The coordinate graph fully reflects the relationship between RNT and cognitive ability; the larger the RNT value, i.e. the longer the repetitive negative thinking, the lower the immediate and delayed memory, i.e. the more pronounced decline.

In response, lead author Natalie Marchant said long-term repetitive negative thinking is an important risk factor for Alzheimer’s disease, and it can lead to AD in an independent way.

As for the specific path of this approach, the researchers are not yet fully clear, and may involve the body’s stress-regulating pathways, such as elevated blood pressure. More exploration will be carried out later.

However, the findings have been positive in the treatment of Alzheimer’s disease.

Dr Richard Isaacson, a neurologist, says:

Studies have shown the biological relationship between repetitive negative thinking and Alzheimer’s disease, providing physicians with a more accurate way to assess risk and tailor treatments to patients.

Why do I tell you to be optimistic?

For older people, long-term repetitive negative emotions increase the risk of Alzheimer’s disease. But for young people, the long-term “lost” transition is not a good thing.

A 2019 study in the medical journal JAMA found that pessimists were more likely to develop cardiovascular disease.

Study finds long-term negative thinking more likely to develop Alzheimer's

Photo credit for JAMA

Dr Alan Rozanski, lead author of the study, said:

Optimists have a 35 percent lower risk of heart complications (including cardiac arrest, stroke, heart attack, etc.) than pessimists.

In addition, the Proceedings of the National Academy of Sciences also pointed to the positive effects of optimism on life and health.

The study showed that people with highlevel optimism had an increased life expectancy by 11 to 15 percent.

Optimists tend to have better health habits, and most are exercised and eat a healthier diet, says Alan Rozanski, a professor of medicine at the Icahn School of Medicine at Mount Sinai. Not only that, optimists will have better ability to deal with problems and processing capacity, able to proactively predict problems, take proactive measures.

On the contrary, negativeists are mostly passive and passive, or “lost”, both in life and in problems.

Not to mention living long, living healthily is also a problem.

Life is not easy, but try to be happy

Previous research has found that only about 25% of optimism is controlled by our genes;

That is to say, they are the master of optimism!

And studies have shown that humans can increase optimism by being able to train their brains. The study noted that 30min of meditation exercises a day, and for two weeks, the brain showed different changes.

In addition, “practicing gratitude” is one way to change your mood.

Take a few minutes a day to write down something to be thankful for, or list the good things you’ve encountered that day, and stay up for a long time to improve your outlook on life and inspire optimism.

But either way, it requires each party to consciously seek change towards the optimistic and positive side.

Study finds long-term negative thinking more likely to develop Alzheimer's

Although everyone’s life is full of bitter sweets, as mentioned in the US drama This Is Us:

All we have to do is make this lemon-like acidin in life into a lemon-soda-like sweetness.

Take the sourest lemon that life has to offer and turned it into smemling lemonade.

Also, don’t forget, the first half of the phrase “the world is not worth” is

“Have fun, friend.”