Scientists at Fudan University have developed an injectable fibrous biosensor that, when implanted, is attached to the skin surface like hair, slim and soft and enables long-term, real-time monitoring of a variety of chemicals in the body. With the development of medical technology, the real-time monitoring of personal physiological information and the individual medical treatment brought about by it have been paid attention to. Electrochemical biosensors are devices that convert chemical signals into electrical signals and can be used to monitor specific chemicals, and are widely used in wearable medical applications.
According to the introduction, the existing implantable sensor because of its material itself large modulus, there is a rigid device and soft tissue between the problem of repeated mechanical damage. In addition, implantable devices based on two-dimensional graphic structure design are difficult to achieve minimally invasive implantation, resulting in difficulty and organization to form a stable interface, can not achieve long-term accurate monitoring, thus affecting signal acquisition and biosecurity.
Peng Huisheng, professor of polymer science at Fudan University, Sun Xuemei, associate professor, Professor of The School of Life Sciences, Yu Hongbo, professor of aerospace, and other multidisciplinary teams have taken a different approach, designing fiber-like electrochemical sensors with multistage spiral structures through the method of bionic muscle structure. Mechanical simulation and nano-indentation experiments have proved that carbon nanotube fibers have lower bending internal stress than traditional implants (golden wire, polydimethylsiloxane, etc.) and that their bending stiffness is closer to soft tissue than other traditional implants. At the same time, the team used injections that matched the fiber’s one-dimensional structure to implant the fibrous sensor accurately into the target area, and the fiber was similar in the form of animal hair attached to the skin surface.
Subsequent cell experiments and tissue slicing showed that the fibrous sensor did not cause inflammatory reactions and scars in the animal after injection, and binds well to the surrounding tissue, and the fiber sensor has excellent biocompatibility and biointegration.
According to reports, this work in the field of bioelectronics to develop a new direction, through integrated circuits, Bluetooth and the corresponding software, fiber-like biosensors can remotely collect physiological data in real time, and the device can work steadily in the blood vessels for up to 4 weeks.