New study reveals diluted plasma reversing aging in mice

A new study by bioengineers at the University of California, Berkeley, has revealed an interesting new way to combat the effects of aging,media New Atlas reported. The team’s study showed that diluting the plasma of older mice reduced the concentration of inflammatory proteins that usually increase with age, which has a powerful regeneration effect on tissues and organs.

New study reveals diluted plasma reversing aging in mice

The new study builds on a study published 15 years ago, when scientists Irina and Michael Conboy of the University of California, Berkeley, found that when older mice and young mice shared blood and organs, they could reverse some of the effects of aging. This has led to extensive research into proteins and molecules that may contain in the blood of young mice that may function as a “spring of youth” and may be used to slow or reverse aging.

After all these years, the couple are still exploring the mysteries of aging and the impact of their ground-breaking research, but they look at it from a slightly different perspective. Researchers have been investigating the idea that, instead of using proteins and molecules in young blood, it may be possible to slow down aging by cleaning up harmful proteins and molecules in the old blood.

“We thought, ‘What if we have some neutral-age blood, some blood that’s not young or not old?’ Michael Conboy said. “We’ll use it as an exchange to see if it improves the situation of older animals. This means making the animals better by diluting the bad things in the blood of older animals. And if something in a young animal goes bad, it means diluting the good things in the young animal source and making the young animal’s condition worse. “

The scientists explored the idea through experiments involving treated plasma, in which part of the animal’s blood was replaced with a special solution consisting of the basic components of physiological saline and the protein albumin. This neutral blood change, which converted half of the plasma of elderly mice into a solution, was found to significantly improve their health. Regeneration of the brain, liver and muscles was the same or stronger as the original 2005 experiment, and the procedure was found to have no adverse effects on the health of young mice.

Using proteomic analysis to study plasma and the protein content in it, the team found that the process resembled a “molecular reset button.” After the exchange, the team observed that as they age, the concentration of pro-inflammatory proteins decreases, and includes beneficial proteins that promote angiogenesis, where they thrive.

“There were two main explanations for our initial experiment,” says Irina Conboy. “The first is that in the mouse joint experiment, young blood and young proteins or factors decrease with age, but the same possible alternative option is that as you age, certain proteins in your blood become more harmful and are removed or neutralized by younger partners.” As our science shows, the second explanation is originally correct. Young blood or factors do not require young blood or factors to play a younger role, and diluting the blood of older mice is sufficient. “

“Some of these proteins are particularly interesting, and in the future we may see them as additional treatment and drug candidates,” says Michael Conboy. “But I would warn against using ‘silver bullets’. Reversing aging by changing any protein is unlikely. In our experiment, we found that we could do a relatively simple procedure and get FDA approval, but it also changed the levels of many proteins in the right direction. “

The study was published in the journal Aging.