Based on the growing link between poor oral health and gastrointestinal disease, a new study by the University of Michigan focuses on the intestinal inflammatory mechanisms that periodontitis may exacerbate in patients with inflammatory bowel disease (IBD),media reported. While much of the study has focused directly on the gut flora, there is growing evidence that oral bacteria can also affect other parts of our body.
Recent studies have revealed a link between poor oral health and high blood pressure. One group of researchers even demonstrated how oral bacteria directly regulate the drop in blood pressure that occurs immediately after exercise.
Researchers have been tracking the link between periodontitis and IBD for years. Recently published meta-analyses confirm the importance of this relationship, but the causality of this relationship has not yet been determined.
The new study is understood to be aimed at exploring mechanisms by oral bacteria that may affect the severity of gastrointestinal diseases. In a collaborative effort involving gastroenterology and dentistry research, the animal study presents a compelling mechanism hypothesis to explain often cited associations.
The first pathway of action proposed in the study proves how periodontitis leads to an increase in certain bacterial species in the mouth. They then observed how the bacteria spread from the mouth to the intestines, where they directly trigger inflammation. Importantly, studies have shown that this pathway does not cause IBD in isolation, as, in general, a healthy gut microbiome is equipped to resist the influx of bad bacteria.
Nobuhiko Kamada, one of the authors of the new study, said: “Normal gut microbiomes are resistant to the settlement of exogenous or foreign bacteria. In mice with IBD, however, healthy gut bacteria are destroyed, which impairs their ability to fight disease-causing bacteria in the mouth. “
The second observation in the study showed that gum disease bacteria activate the production of immune T-cells in the mouth. These immune cells are then seen migrating to the intestines, which increases inflammation of the gastrointestinal tract.
William Giannobile, co-author of the study, explained: “This increase in intestinal inflammation is caused by the migration of oral microbes to the intestines, which has a significant impact on the stress that patients urgently need oral health as part of their overall health and well-being.” “
In addition, the study cautions, the study adds that there is no evidence that either of these behaviors occurs in healthy people. This means that there is no evidence that oral disease is the only cause of gastrointestinal inflammation. Instead, this IBD deterioration requires pre-existing imbalances in the gut microbiome.
Shrinivas Bishu, another co-author of the study, said the study showed the likely causes of some IBD patients resisting treatment more than others and suggested that monitoring patients’ oral health could be another practical tool for managing intestinal inflammation.
The study has been published in Cell.