A growing body of academic research and clinical evidence in patients with the new crown show that the new coronavirus virus destroys insulin-producing cells in the body, causing diabetes in healthy people. To that end, scientists have begun to move to build a database to collect information on COVID-19 patients with no history of diabetes or blood sugar control problems.
For most people with type 1 diabetes, the body’s immune cells begin to destroy the cells in the pancreas, the cells responsible for producing the hormone insulin, a process that is usually sudden. Diabetes has been identified as a key risk factor for severe infections in new crowns, and people with diabetes are more likely to die. “If you have COVID-19, diabetes is fatal,” said Paul Zimmet, a metabolic disease researcher at Monash University in Melbourne, Australia, as cited by Nature. “
Now, a growing number of researchers, including Zimmet, believe that diabetes not only makes people more susceptible to coronavirus, but that the virus can also cause diabetes in some people.
It is worth noting that on June 19th, an international group of 20 top experts in diabetes and endocrinology, including Professor Ji Linon, Director of the Endocrinology Department of Peking University People’s Hospital and Director of the Diabetes Center of Peking University, also published the Practical Recommendations for the Management of New Coronary VirusEs combined with DiabeticS in The Lancet. Older diabetics with neo-coronary pneumonia are at higher risk of dying from the disease, the paper said. At the same time, the new coronavirus may actually promote normal people to become new diabetics.
In fact, previous scientific findings have shown that various viruses, including SARS-CoV, are associated with autoimmune diseases such as type 1 diabetes. Many of the organs involved in controlling blood sugar are rich in a protein called ACE2 (Angiotensin-converting enzyme 2), which is also the receptor used by SARS-CoV-2 to infect cells.
The latest leads come from an experimental study published last week in a small laboratory cultured pancreas that suggests the virus can cause diabetes by destroying cells that control blood sugar. But other researchers are cautious. “We still need to keep a close eye on the incidence of diabetes in people with a history of COVID-19 and determine whether the incidence is above expectations,” said Naveed Sattar, a metabolic disease researcher at the University of Glasgow in the UK. “
Abd Tahrani, a clinical scientist at the University of Birmingham in the UK, says researchers need stronger evidence to establish a link between the two. “There is a need for well-structured epidemiological cohort studies, as well as mechanism and experimental studies,” he said. “
An initiative is under way to establish a library of diabetes data for new crown patients. Earlier in June, an international team of scientists, including Zimmet, set up a global database to collect information on COVID-19 patients with no history of diabetes or blood sugar control problems.
Stefan Bornstein, a physician at the Technical University of Dresden in Germany who was also involved in the database, said similar associated cases are beginning to emerge slowly. The researchers hope to see if SARS-CoV-2 can trigger type 1 diabetes or a new type of diabetes. They wanted to investigate whether a sudden episode of diabetes became permanent in patients with COVID-19. They also want to know whether the virus will turn patients already developing type 2 diabetes into diabetics.
Studies of pancreatic organs show how SARS-CoV-2 damages pancreatic tissue. The stem cell biology team at Weill Cornell Medical School in New York has shown that viruses can infect organ-like classes and cells, some of which can die. Cells produce insulin to lower blood sugar levels, while cells produce glucagon, which raises blood sugar. According to a study published June 19 in the journal Cell Stem Cell, the virus can also induce the production of proteins such as chemogens and cytokines, which trigger immune responses that can also kill cells.
Experiments have shown that the virus can disrupt the function of key cells associated with diabetes by killing them directly or triggering an immune response that attacks them. The virus also attacked pancreatic and liver organ cells transplanted into mice. When the liver perceives insulin, it is important to store and release sugar into the blood.