Study: Antibody test results may be negative in mildly infected with the new coronavirus.

According tomedia reports, the new crown pneumonia immunity is currently one of the most important research topics, but the new crown virus is too new to give researchers the most important question a clear answer: That is, is it possible to re-infect? The management of the outbreak and future vaccination policies may depend on this answer. The researchers believe the new coronavirus will be immune to other human coronaviruses, meaning the body will be protected for six to 12 months, but may then be re-infected.

Study: Antibody test results may be negative in mildly infected with the new coronavirus.


In addition, researchers are seeking to measure the actual number of cases of new coronal pneumonia in a community by conducting antibody tests. These are specific “witnesses” to the infection, proving that the immune system has eliminated the new coronavirus and is ready to stop it again in the event of a second infection. Recent studies, however, have shown that antibodies disappear from the blood two to three months after the first infection. But the immune system still has specialized T cells for a second contact with the virus, so this means that the immune system does not lose its function when the antibody disappears. However, antibody testing cannot detect T cells, which is a separate, more difficult test.

Now, a new study suggests that antibody tests cannot detect people with mild neo-coronavirus infection, which can be a real problem in all cases. This is not to say that mildly infected people do not produce an immune response. But the current tests are used in samples from patients with symptoms who are often hospitalized.

The oxford study, which recruited more than 9,000 health care workers, is understood to have shown that a significant number of people have tested negative for antibodies, despite the possibility of contracting the virus. The researchers used a particular condition associated with neo-coronary pneumonia — sudden loss of smell and taste — as a basis for their judgment. Several other studies have revealed why this occurs and showed that patients are likely to test positive after experiencing new coronary pneumonia. Not all infected people have this condition. This is why PCR tests are still needed to correctly diagnose the disease.

Research by the University of Oxford found that 47 per cent of the 903 people who tested positive for the antibody reported losing their sense of smell or taste. But there was also a group of subjects who felt below the antibody-positive threshold, meaning they did not carry the virus. However, 30 per cent of them also reported losing their sense of taste or smell, and given the small proportion number, it could not be explained by another condition that could lead to sudden loss of smell and taste.

Only 3 percent of common cold patients experience loss of smell and taste, the researchers said.

The study also showed that about 387 people who tested below the threshold had no symptoms. These may all be asymptomatic patients with neo-coronary pneumonia, but researchers are unable to prove that they carried the virus.

The scientists used several antibody tests, including the Abbott diagnosis used in a quarter of the antibody tests in the UK. The results showed that the sensitivity of the experiment was lower than it is currently thought. According to the researchers, the test will reduce sensitivity by 11 percent, rather than 98 percent. In other words, the test will miss a large number of new coronal pneumonia survivors. The reason for this is simple. The test was designed using samples of patients with symptoms treated at the hospital for the treatment of new coronary pneumonia.

To do this, the scientists suggested that samples from patients with mild and asymptomatic pneumonia who had been tested by PCR and confirmed to be infected could be used to improve the test to identify patients with low antibody counts.

On the other hand, these tests are designed to ensure that they do not give false positive results. Telling uninfected people that they have antibodies can lead to a false sense of security, but they can be infected.

Commenting on the study, the British government said, “We do not yet know whether antibodies indicate immunity to reinfection with the virus, or whether they can prevent transmission.” A spokesman for the Department of Health and Social Welfare said: “Antibody testing is an important part of our testing strategy because it helps us understand how the new coronavirus is spreading across the country. “

But if the Oxford University study can be confirmed, antibody testing won’t help officials understand how the disease spreads in the community. Coupled with studies showing that antibodies disappear three months after infection, this poses another problem for the study group immunity.