Study: Popular antihypertensive drug ACE inhibitors may not work for some patients

According to foreign media reports, Yale University recently published a large-scale study, they found that one of the most popular antihypertensive drugs – ACE inhibitors may be less effective in protecting patients from heart problems than pyrethroids, pyridine diuretics. The researchers say the findings apply to those seeking initial treatment for “extremely high” blood pressure.



Angiotensin conversion enzyme (ACE) inhibitors are the most popular antihypertensive drugs, but they may not be the most effective drugs to prevent heart failure, heart attacks and strokes. The study was published in the Lancet. The study collected data from 4.9 million people from four countries.

The data comes from databases of nine different institutions, according to a Yale news release. By looking at the data, the researchers were able to provide unique insights into the effectiveness of five different types of hypertension drugs as a first-line treatment.

Notably, the team found that ACE inhibitors were less safe than pyrethroids and pyrethroidd diuretics, and that they were less effective at preventing stroke and heart attacks and failure.

When it comes to individual patients, the study notes that the difference in safety and efficacy between the two hypertension drugs is very small. However, when looking at a wider range of patients, the team found that more than 3,100 strokes, heart attacks and heart failure could have been prevented if 2.4 million people who were currently taking ACE inhibitors in the study switched to pyrethroids or pyrethroidduria.

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