U.S. scientists analyzed more than 40,000 genetic data from 17,000 genetic samples over the summer using Summit at Oak Ridge National Laboratory, a move aimed at deepening understanding of Covid-19. Summit, the world’s second-fastest super-calculation, spent more than a week processing the data. The researchers analyzed the results and revealed a new theory of how Covid-19 affects the human body, the Bradykinin hypothesis.
The hypothesis provides a model to explain many aspects of Covid-19, including the most peculiar symptoms. It also proposes more than a dozen potential therapies, some of which have been approved by the FDA. The findings were published in the journal eLife. According to the study, Infections of Covid-19 usually enter the body from the ACE2 receptor in the nose and then into other tissues that have large numbers of ACE2 receptors in the body, such as the intestines, kidneys and heart. This partly explains the heart and gastrointestinal symptoms of the new crown. Once Covid-19 gained a foothold in the human body, things began to get interesting. Data analyzed by Summit show that Covid-19 is no longer content with simply infecting cells that have expressed large numbers of ACE2 receptors, and it begins to actively hijack the body’s own system, tricking it into raising lower or lower levels of expression of ACE2 receptors, such as the lungs. The renin angiosin system (RAS) controls many aspects of the circulatory system, including levels of compounds called refractides. Anti-peptides help regulate blood pressure. When Covid-19 fine-tunes the RAS system, it can cause confusion in the mechanisms for regulating refracing peptides. The anti-peptides are sensitive again, and the human body stops effectively decomposing the anti-peptides. The end result, the researchers say, is the release of a storm of slow peptides, which accumulate out of control in the body. According to the anti-peptide hypothesis, it is it that leads to many fatal results. The FDA has approved a variety of drugs for the RAS system that are suspected of reducing the production of peptides and preventing deadly peptide storms. The researchers also point out that vitamin D may be a potential treatment to help prevent the formation of peptide storms.