“Reference News” published on the 7th of the U.S. daily science website reported that “the risk of Alzheimer’s disease related to common drugs.” A team of scientists led by researchers at the University of California, San Diego School of Medicine says drugs that treat diseases such as allergies, colds, high blood pressure and urinary incontinence may increase the risk of cognitive decline, especially in older people.
The findings were published September 2, 2020 on the website of the Journal of Neurology, a medical journal of the American Academy of Neurology.
At present, anticholinel energy drugs are widely used to treat dozens of diseases, large and small. Some of these anticholinel drugs require a doctor’s prescription to buy, while others can be purchased directly over the counter at the pharmacy. They work by preventing acetylcholine, a neurotransmitter or chemical messenger vital to memory function, from binding to a subject on a particular nerve cell. The effect is to suppress side-sensing nerve impulses, which are associated with a variety of unconscious muscle activities, such as muscle activity in the gastrointestinal tract and lungs, as well as physiological functions such as salivation, digestion and urination.
The researchers said that when cognitively normal subjects took at least one anticholine energy drug at a baseline and were followed for 10 years, they were 47 percent more likely to develop mild cognitive impairment than 20 percent who did not. Mild cognitive impairment is often a precursor to dementia such as Alzheimer’s disease.
Study co-author Dr Lisa Delano-Wood, an associate professor in the Department of Psychiatry at the University of California, San Diego School of Medicine, said: “This study suggests that reducing the use of anticholinear drugs before cognitive problems occur may be important in preventing negative effects on memory and thinking skills in the future, especially in people at greater risk of Alzheimer’s disease.” “
688 adults with an average age of 74 participated in the study and were grouped by sex. At the beginning of the study, none of the subjects had cognitive or memory problems and reported whether they were taking anticholinear drugs. One-third of them took an average of 4.7 anticholinel drugs per person. The subjects underwent an annual comprehensive cognitive test for up to 10 years.