In recent decades, diabetes has become one of the global diseases threatening human health. Among them, type 1 diabetes accounted for about 10%, mainly insulin deficiency, mostly in childhood or admins. In the treatment of type 1 diabetes, insulin-producing beta cells are essential. Islet transplantation is the most effective beta cell replacement therapy for accurate blood sugar control.
(Original title: Natural Journal: New islet cell subsutercies transplantation method or improvement of type 1 diabetes treatment)
Journalist He Liping.
It is worth noting that in some patients with type 1 diabetes clinically transplant islet cells into the liver, but this treatment can lead to complications such as bleeding, thrombosis, and rejection of the graft.
At 2 p.m. Beijing time on September 7, researchers from the University of Pennsylvania and others said they had developed a new method of subsothebic transplantation that would keep blood sugar levels in animal models of type 1 diabetes stable.
The findings may be important for improving the treatment of this autoimmune disease. The paper is co-authored by Ali Naji, a professor of surgery at the University of Pennsylvania School of Medicine, an internationally renowned transplant surgeon and immunologist.
The paper mentions that the location of insorisal transplantation is of concern because they are easier to reach and monitor, and that the location represents another safe and convenient islet transplant location. But the new problem is that the lack of new blood vessel formation and the resulting death of low-oxygen cells greatly limit the life and function of the graft, which also hinders the widespread clinical use of islet transplantation.
In the study, the team overcame these problems by wrapping islet cells in a new collagen substation that helps cells survive subsurfic transplantation.
The team also used rodents, pigs and human islets to verify that their transplant methods provided consistently normal blood sugar and demonstrated their effectiveness in non-human primate islet transplant models.
The team also believes that their method could also be used to improve the viability of other types of transplanted cells. For example, if beta cells from stem cell sources can also be treated in this way, they may become a renewable source of insulin secretion cells, replacing those lost in people with type 1 diabetes.
The team concluded that it was a simple, safe and repeatable way for animals in the experiment to maintain normal production of insulin and glucosin. “Although further research is needed, islet off-cortic transplantation may provide a new treatment option for people with type 1 diabetes.”