According tomedia reports, although antibiotics are very good, but there are serious shortcomings. Over time, bacteria have developed resistance to many of the most commonly used antibiotics, creating what scientists call “superbugs.” These antibiotic-resistant bacteria pose a serious threat because of their ability to flourish and potentially spread rapidly.
Now researchers from the University of Sheffield have developed a compound they say kills two antibiotic-resistant bacteria. The compound can attack both Gloren-positive bacteria and Gloran-negative bacteria — although the cell wall structures of the two bacteria are different.
Combating antibiotic-resistant bacteria is clearly a challenge for doctors. Some antibiotics are used in small amounts when resistant bacteria are found, but when they are used, doctors also risk allowing bacteria to evolve again against so-called “last resort” antibiotics.
Of these two types of antibiotic-resistant bacteria, Gloren’s negative bacteria have the greatest problem. Glostic bacteria are known to be highly adaptable to the most common treatments, and as researchers noted in a press release, they have developed a compound that fights Terrain-negative bacteria. The new compound targets both, making it more flexible in treating “superbug” infections.
Professor Jim Thomas, who led the study, said in a statement: “Antimicrobial resistance is a growing problem, with many studies predicting a global medical emergency and the urgent need to combat broad-spectrum antibiotics from drug-resistant pathogens. “
The compound, developed by Thomas and his team, attacks bacteria by destroying cell walls and attaching them to DNA. Doing so can make bacteria very fragile. While Gloran-negative bacteria are usually more resistant to this type of attack, the researchers say their new compounds have proven them to be up to the task.
Because the new drug can attack a wide range of bacteria, it is considered broad-spectrum, which is both a good and a bad thing. Broad-spectrum antimicrobials work well at killing many different types of harmful bacteria, but on the other hand they can inadvertently remove beneficial bacteria such as the intestines in certain parts of the body. Intestinal health and the stability of the human microbiome are essential for health, so the use of strong antibiotics is a balancing act.
Looking ahead, researchers will face many obstacles before their compounds can be used to fight bacteria in humans.