Scientists woven arterial grafts with collagen and synthetic fibers.

在面向心脏病患者的手术治疗过程中,往往需要用到特殊材料来替换冠状动脉中受损或阻塞的部分。然而一项新的概念研究,预示了将来无需从患者自体(通常来自腿部静脉)来取换,而是能够直接通过生物合成纱线来织造移植物。作为一个支架,其使得患者自身细胞有足够的机会来生长和修复动脉。

Scientists woven arterial grafts with collagen and synthetic fibers.

原型织造示例(图自:Fan Zhang)

It is reported that the most commonly used method in clinical treatment is to replace the coronary arteries in other parts of the patient’s body. This is not only invasive, it does not adequately take into account the absence of replaceable parts in the body of some patients.

有鉴于此,来自北卡罗来纳州立大学(NC State)和凯斯西储大学(CWRU)的一支研究团队,就想到了通过生物工程材料来提供血管移植物的方法。

To find this alternative, they mixed two types of fibers into a yarn and then made arterial substitutes with a circular loom, according to Fan Zhang, a researcher.

其中一种纤维为胶原蛋白,另一种则是由聚乳酸制成的合成纤维。将两者结合之后,成品可像真人移植物一样膨胀和收缩。

虽然并非一种永久性的植入物,但这套仿生支架仍有助于患者发动自身细胞来重建新动脉。通常在动脉内部排列的那些内皮细胞,会粘附在支架上并开始生长。

与仅使用了合成材料的产品相比,胶原蛋白可帮助这些细胞更好地粘附于支架上。混合纱线可将初期的细胞粘附能力提升 10 倍,最终细胞数量也提升了 3.2 倍。

Scientists woven arterial grafts with collagen and synthetic fibers.

(来自:NCSU)

研究合著者 Martin King 表示:“我们并非在设计一种最终产品的原型,而是在添加使患者能够治愈的成分,并借助这种构造来起到冠状动脉的作用,纤维最终可被人体讲解和吸收”。

These synthetic fibers can be degraded to lactic acid, which is more common in humans and contains very low levels. The main problem is that the form of this material is too porous, leading to blood transmission. Before clinical trials, research teams still need to work to overcome this deficiency.

有关这项研究的细节,已经发表在近日出版的《材料科学与工程 C 刊》(Materials Science and Engineering: C)上。

原标题为《A hybrid vascular graft harnessing the superior mechanical properties of synthetic fibers and the biological performance of collagen filaments》。