A recent study in India found that certain areas of human DNA are protected from radiation, a finding that is crucial to maintaining the stability of the human genome. The findings were published online in the american journal iScience, a subsidiary of Cell Press. The human genome is constantly challenged by endogenous and exogenous damage, and maintaining genomic stability is critical to the survival of any organism.
Picture from the hindu
Among the external factors, ionizing radiation is the most important factor causing DNA damage, which can lead to single-stranded and double-stranded fractures. The general view is that ionizing radiation randomly induces DNA strands to break.
To study the relationship between DNA structural type and radiation resistance, researchers at the Indian Institute of Science began testing on single-stranded DNA. When a DNA strand consisting entirely of one of the four nucleotides (adenoid, cytosine, otoma, or thymus) is exposed to gamma rays, all DNA strands are sensitive to rays except the DNA strands made up of ostrich. When half of a DNA chain contains thymus and the other half contains ostrich, only half of the ostrich show better radiation resistance.
The researchers then tested the radiation resistance of related structures made up of ostrich in experiments and found that the advanced structure of G-tetrastrand DNA, rich in series and repeating ostrich (G), was the most resistant to radiation.
The researchers say the results show that the G-tetra-strand structure prevents radiation-induced DNA from breaking and is more resistant to radiation, and That G-tetralink DNA is an important factor in the differences in radiation sensitivity in the human genome.