Scientists at the University of Toronto are working on a new drug to help people quit smoking, which can block nicotine pleasure and make people sick at once,media reported. Scientists have found chemical shifts in the brain when people smoke, including nicotine and the way people get more pleasure than disgust, the report said.
The new drug will block the pleasure pathways and make people feel sick when they smoke.
The researchers note that nicotine triggers the brain’s reward system and aversion responses, stimulating the brain’s receptors dopamine and gamma-aminobutyric acid (GABA). In fact, people’s aversion to smoking has always existed, but with the increase in smoking, dopamine increase, people feel that nicotine is good rather than bad, so that people become addicted.
Dopamine has long been considered a happy chemical and a neurotransmitter involved in signaling. Excessive dopamine or cause schizophrenia, too little dopamine or Parkinson’s disease.
Scientists will target GABA receptors without interfering with dopamine, developing smoking cessation drugs to help people quit smoking.