Many diseases affect human ability to breathe. Some are caused by smoking, while other lung problems may be caused by inhaled chemicals or other substances. The biggest problem for people with lung and lung diseases is that they cannot breathe and have an impact on every aspect of their lives. Now researchers at Yale University have announced that they have created a blueprint for cells in the human lungs.
Researchers say the new blueprint will make it easier for people to understand the mechanisms behind lung function and disease. This new development may also make future new lung bioengineering possible. The data is obtained through single-cell technology, which provides an ultra-high-resolution view of up to millions of individual cells at a time.
Using this high-resolution observation, the team was able to detect the interaction of key lung cells in different species, including mice, mice, pigs and humans. The data reveal several common cellular communication networks that drive functions such as cell regulation, disease surveillance, and cell signaling. These data provide new insights into the mechanisms behind lung development and disease.
One of the scientists said the team could take entire organs or tissues and measure all cell types from a snapshot. Five years ago, the resolution required to study individual cells was not available, the team said. There are 40 different types of cells in the lungs, the team notes.
Scientists involved in the project point out that the ability to build regenerative lung tissue and regenerative lungs for human tissue is the holy grail of science. Currently, the only way to treat end-stage lung disease is a lung transplant, but this requires immunosuppressive drugs and is often rejected by the immune system after transplantation.