Proteins and Cells, an international authoritative academic journal headed by the Ministry of Education, recently published the latest results of Chinese scientists: by injecting embryonic stem cells from monkeys into pig embryos, two “pig monkey shimmerses” were produced, and “master brothers” and “two brothers” were first combined. The authors are three, all from the National Key Laboratory of Stem Cell and Reproductive Biology of the Institute of Zoology of the Chinese Academy of Sciences, Dr. Hai Yu, who is engaged in the construction of a humanized pig model, Li Wei, deputy director of the National Key Laboratory of Stem Cells and Reproductive Biology, and Zhou Qi, a member of the Chinese Academy of Sciences and director of the Institute of Animals.
Researchers have added fluorescent protein GFP to crab monkey cells to track cells and their progenitors. After obtaining traceable embryonic stem cells, the researchers injected them into pig embryos five days after fertilization, injecting a total of 4,359 blasts and eventually obtaining three chimeric embryos, one of which was unfortunately aborted.
Of the last 10 piglets, two were identified as pig-eating crab monkeys.
The process of producing the “pig monkey chimeric”
The researchers say the study confirms that the chimerals of pig-eating crab monkeys can grow functional liver and kidney cells in pigs that can be used for further clinical applications.
But heterogeneous chimerics are applied to the clinic, and there are two other obstacles: the need to improve the chimeric rate, and the need to understand the molecular mechanisms of heterogeneous evolutionary differences, which affect the developmental efficiency of heterogeneous chimerics.
Next, the researchers hope to create organs made entirely of monkey cells.