According tomedia reports, when a fracture occurs, the body will be with a healing biochemical substance called adenosine filled the damaged area. A new bandage is designed to absorb the substance and keep it around so it can do more work.
Often, adenosine that naturally appears in bone damage sites is quickly metabolized by the body. This stops the healing “boost” that the chemical originally provided. Led by Professor Shyni Varghese, scientists at Duke University in North Carolina set out to develop a way to “capture and hide” adenosine at the injured site, enabling it to perform its healing “duty” for a longer period of time.
The prototype bandages they developed could be surgically applied directly to fractured bones. It combines boric acid molecules, which form bonds with adenosine molecules present at the site of damage. As these bonds fade, adenosine is released slowly – but only when needed.
“Adenosine is common in the human body, has very low levels, and performs many important functions that are not related to bone healing,” Varghese said. To avoid harmful side effects, we must find a way to locate adenosine on damaged tissue and maintain an appropriate level. “
In laboratory tests, the researchers treated the fractured bones of mice with three types of bandages. These include bandages designed to preserve adenosine produced by animals, bandages that have been “triggered” with adenosine, and bandages that do not contain or capture chemicals.
After three weeks, although all mice showed signs of healing, mice treated with two types of adenosine bandages showed better bone formation, higher bone mass and better vascular formation. Infusion straps may be particularly useful for osteoporosis patients.
Scientists are now working to improve the ability of bandages to retain adenosine and are further studying potential side effects. They hope to eventually create a product that can be biodegraded harmlessly after the job is done.
The paper on the study was published this week in the journal Advanced Materials.