Recently, according tomedia reports, Osaka University, Japan, microbial disease research and research and Japan’s National Institute of Infections to develop a “nasal spray vaccine”, only by spraying into the nasal cavity can prevent influenza, inoculation painless, the elderly and young children are available. The report said the institute has completed clinical trials for the vaccine to test human safety and efficacy, and plans to apply to the state for approval in the near future.
It is reported that the nasal spray vaccine is composed of non-infectious influenza virus, into the nasal cavity and throat of the mucous membrane, the body’s immune function will become active, the surface of the mucous membrane will release a large number of antibodies to prevent the virus from invading the human body. Vaccination is painless and can be used for the elderly and infants.
At the same time, the researchers note, antibodies can form in the blood that attack the invading virus and inhibit its reproduction.
Experiments showed that after using 2 nasal spray vaccine, the frequency of nasal mucosa antibody activity was about 3 times higher than the injection of 1 vaccine. And nasal spray vaccines are expected to have an effect on various types of influenza viruses.
The researchers infected mice vaccinated against the H5N1 subtype virus h3N2 and found that all the mice vaccinated had died, while those vaccinated against the nasal spray survived about 80 percent.
But side effects have not yet been announced, which may include symptoms such as runny nose, fever and sore throat.
The nasal spray vaccine is expected to be used in other diseases, and could be extended to periodontitis and hepatitis B, the researchers said.