Some scientists have been trying to repair bone damage with a bone-forming protein called bone-forming protein, the new media new Atlas reported. It does have some limitations, but they can be overcome by using new biological materials. One of the main problems with bone morphological protein (BMP) is that it not only causes new bones to grow in the injured area, but also in the surrounding soft tissue. This happens because proteins are leaked from materials such as biodegradable collagen sponges, which are designed to remain in the area.
The University of Oregon team, led by bioengineer Marian H. Hettiaratchi, is working on combining BMP with alginate gels and now medically recognized anticoagulants. BMP binds to the herapin particles, and the gel gives the binding a substance that has a lasting effect.
In laboratory tests, the researchers injected the material into nanotubes that had been inserted into the femur damage in rats. The results were encouraging, with “ectopic bone” (unwanted bone growth) reduced by 50% compared to BMP in sponges.
“The clinical problem with treating large bone defects is that BMP delivered using collagen sponges can lead to abnormal bone formation because the drug does not stay on the material,” Hettiaratchi said. Our new material retains more BMP to keep it localized. You do not form bone formation outside the target area. “
Because herapin does have some side effects, the team is now working on a synthetic alternative specifically designed to treat bone damage with BMP.
The paper on the study was published this week in the journal Science Advances.