Aging is a topic that is relevant to everyone, and finding ways to slow it down can help reduce diseases. Thanks to the tireless efforts of scientists, the research project has finally made a breakthrough, and the way in which cells have been adjusted has succeeded in extending the lifespan of worms by 500 percent.
Beautiful hidden bar nematode (C. Elegans) is a very small worm, and in the eyes of scientists it is the target of research into aging. This is mainly because it has the same cellular pathway as many humans, and usually lasts 3-4 weeks, so any changeins in life can be seen more quickly and easily measured.
In the past, scientists have managed to use drugs or genetic engineering to extend the life span of the beautiful hidden nematode by 50 or 100 percent. If put in humans, that means the average life expectancy can be increased from 80 to 120 to 160 years. But in the latest study, the team accidentally made the worm five times longer than usual, equivalent to extending a human life span to 400 years.
The researchers made changes to the worm in two ways, including the worm’s insulin signaling pathway (IIS) and toR signaling pathway. Past studies have shown that changing the IIS pathway can increase life expectancy by 100 percent, while changing the TOR pathway can increase life by 30 percent. In theory, the two approaches should be 130%, but the actual test research effect can reach 500%.
“This synergy is really crazy,” said Jarrod Rollins, lead author of the study. The effect is not that a simple OnePlus is equal to two, but one Plus one equals five. In order to develop the most effective anti-aging treatments, we must focus on the longevity network rather than the individual approach. “
The study was published in the journal Cell Reports.
Source: MDI Biolab