Getting enough exercise is difficult for the elderly, injured or disabled, but with new research, it has been found that an existing protein may change that,media reported. Previous studies have shown that a natural protein called Sestrin accumulates in the muscles after intense exercise. So scientists at the University of Michigan wanted to know whether artificially raising animal Sestrin levels could have a protein-related beneficial effect.
To do this, they first studied three groups of fruit flies: one for the normal group, one for a group that lacked the ability to generate Sestrin, and one group that was transformed into an overexpression of Sestrin. All three groups underwent three weeks of physical training on a small treadmill designed by Wayne State University in Detroit.
The scientists then tested the fruit flies’ ability to run and fly for long periods of time, and found that the ability of normal fruit flies improved, fruit flies lacking Sestrin did not improve, and those that expressed protein showed greater improvement than normal fruit flies — even if the fruit flies in the middle group did not exercise any exercise.
It seems that this protein may not just increase durability.
Mice lacking Sestrin did not improve as expected in terms of aerobic, breathing and fat burning. In a related study conducted at the University of Pompeii-Fabra in Spain, Sestrin was found to prevent muscle atrophy — a finding that may be particularly useful for people who wrap injured limbs in plaster.
“We think Sestrin can coordinate these biological activities by turning on or off different metabolic pathways,” said Jun Hee Lee, a professor at the University of Michigan who co-authored the study with myungjin Kim, an assistant professor. “
Now, scientists are further exploring how Sestrin is produced in the body and studying the development of supplements that contain this protein.