How does mycobacterium tuberculosis cause disease? Tongji University School of Medicine, Tongji University affiliated Shanghai Lung Hospital, Professor Gobao Professor research team, in conjunction with Shanghai University of Science and Technology Institute of Immunochemistry Rao zi and academician research team recently found that TB bacteria have a secreted protein is very “smart”, it can use the human protein molecules to attack their own immune function, thereby producing toxic forces, Causes the occurrence of tuberculosis.
It has been found that when the human body is infected with TB bacteria, TB bacteria can secrete the toxic factor Rv0222, and Rv0222 using the human protein modification system after secondary processing, can effectively resist attacks from the human immune system, resulting in TB bacteria from the human immune system successfully escape and disease.
Professor Zhao Guoping, a member of the Chinese Academy of Sciences, and Xiao Ping, a former member of the Chinese Medical Association’s Tuberculosis Credit Committee and professor Xiao Ping of the Shanghai Lung Hospital affiliated with Tongji University, said the study fully illustrates the escape mechanism of TB bacteria using the human ubiquitinization system to protect against human immune attacks. This protein modification system to human protein modification system to help TB bacteria infection disease-causing new mechanism of discovery, broaden the protein modification system in the regulation of infectious diseases.
At the same time, through protein structure analysis and functional exploration, the researchers pointed out precisely that Rv0222 toxic protein is the K-11 ubiquity modification on its 76-bit lysine, which can provide a more accurate target for the development of new anti-tb drugs in the follow-up study.
This important medical research results, entitled “TB protein strains immunization using host ubiquitization system”, were published online in nature on the 16th.