The joint emergency response team of the Shanghai Institute of Pharmaceutical Research and the Institute of Immunochemistry of the University of Science and Technology of China, led by Academician Jiang Hualiang and Rao Zi and academician, and with the participation of more than 20 subject groups, carried out anti-2019-nCoV drug research using the experience gained from the previous anti-SARS drug research.
On the basis of the rapid expression of the 2019-nCoV hydrolysis enzyme (Mpro) and the high-resolution crystal structure, the joint team combined a combination of virtual screening and enzymatic testing, focusing on listed drugs and self-built “high-drug compound databases” and The “Database of Pharmaceutical Plant Source Compound Ingredients” was screened for drugs and quickly identified 30 drugs, active natural products and traditional Chinese medicines that may have therapeutic effects on 2019-nCoV (see schedule), and recommended that consideration and attention be given to the clinical treatment of patients with pneumonia infection in 2019-nCoV. The research team will continue to conduct targeted anti-2019-nCoV activity tests to provide more direct guidance for clinical research and treatment.
Candidates include 12 anti-HIV drugs, including protease inhibitors Indinavir, Saquinavir, Lopinavir, Carfilzomib, and ritonavir. 2 anti-respiratory syncytial virus drugs, 1 anti-human macrophage virus drugs, 1 anti-schizophrenic drug, 1 immunosuppressant and 2 other drugs; On the basis of early anti-SARS research and computer simulation, it was found that the old drug cinnamon thiamine and cyclosporine A may be effective in 2019-nCoV, of which cinnamon thiamine was used in the 1970s to fight schizophrenia, and had an inhibitory effect on coronavirus 3CL hydrolysise. Immunosuppressant cyclosporine A can prevent the virus’s nucleosporin protein and human cyclosporine A combination, there are studies that have shown that co-use interferon and cyclosporine A can significantly inhibit coronavirus replication and tissue damage in human bronchial and lung. Their study also found that Chinese herbs such as tiger sticks and mountain bean roots may contain active ingredients resistant to 2019-nCoV.
The emergency attack team has completed the synthesis process of kilograms such as cinnamon thiamine, preparation work is under way, the preparation process of the capsule preparation of cyclosporine A has been completed, and the synthesis process of other drugs has been completed. We welcome companies and research institutions to work with us to combat 2019-nCoV.