New coronavirus mRNA vaccine development official project is expected to complete large-scale production preparation within 40 days

It is reported that Tongji University affiliated Oriental Hospital Conversion Medicine Platform and Stemirna (Shanghai) Biotech Co., Ltd., relying on the “Shanghai Zhangjiang National Independent Innovation Demonstration Zone Stem Cell Strategy Library and Stem Cell Technology Clinical Transformation Platform” task – mRNA synthesis platform results, to rapidly promote the development of the new coronavirus mRNA vaccine. Recently, the project has been urgently completed project filing.

New coronavirus mRNA vaccine development official project is expected to complete large-scale production preparation within 40 days

New coronavirus mRNA vaccine development official project is expected to complete large-scale production preparation within 40 days

The research and development of conventional vaccines is divided into three stages: discovery verification, preclinical and clinical period, some of which may last several years and cost hundreds of millions of dollars. Li Hangwen, chairman of the Part-time PI and Microbes of Oriental Hospital Translational Medicine Platform, said that using the relevant platform technology to quickly synthesize mRNAs for a variety of different antigen sequences for the key targets of this new coronavirus, and to prepare them into preparations through nanolipid (LPP) drug-carrying technology, through in vivo and animal experiments. Screening and validating effective antigens, on this basis will be able to complete large-scale preventive 2019-nCoV vaccine sample production, preparation within 40 days.

After the vaccine sample is produced, it can be sent to the designated national institutions to carry out the anti-new coronavirus activity test, after the completion of the necessary approval, can be introduced to the clinic as soon as possible.

Preventive vaccines are key to fighting a pandemic of major and sudden infectious diseases. In response to the 2019-nCoV epidemic, traditional vaccines have too long production cycleproblems, such as recombinant protein vaccine production cycle of 5 to 6 months, can not meet the need to put out the outbreak in a timely manner.

The new generation of mRNA vaccine technology, which has emerged in recent years, has the advantage of short development and production cycle, and can realize the timely production and application of vaccines.

New coronavirus mRNA vaccine development official project is expected to complete large-scale production preparation within 40 days