Scientists discover how ovaries age: New ways to treat human infertility

On January 30th a joint team of researchers from the United States and China published a new study in Cell found how the ovaries of non-human primates age, and revealed several genes that can be used as biomarkers, pointing out that they can be used to diagnose and treat female infertility and age-related diseases in women. such as ovarian cancer).

Scientists discover how ovaries age: New ways to treat human infertility

The ovaries are a complex reproductive organ, and current research shows that women are born with a certain number of oocytes, and once a woman reaches the age of 35, the function of the oocytes begins to decline, leading to infertility. A better understanding of the ovarian environment and the mechanisms of healthy aging could provide new treatments for women with fertility problems.

The scientists compared 2,601 ovarian cells from young and elderly non-human primates and determined the genetic activity patterns of each primate’s ovarian cells, including egg cells and granule cells that surround the oocytes during the development of oocytes.

Similar to previous studies of rodents, scientists have observed changes in the function of non-human primate cells related to cell stress and cell division. As oocytes and granules age, some genes that fight cell stress become inactive, leading to impaired function.

The scientists then compared data from primates with granules in healthy women between the ages of 21 and 46. The results showed that two antioxidant genes (IDH1 and NDUFB10) played a key role in protecting human and non-human primate ovarian cells from cellular stress during aging. These genes are promising biomarkers or therapeutic targets for diagnosis and treatment with declining ovaries and age.

The researchers say the study provides a comprehensive understanding of the specific mechanismby by which primate ovaries age at single-cell resolution, which could provide new aids for the regeneration of older ovarian cells. And we were able to identify new biomarkers that could be therapy that helps maintain fertility.