Scientific commandos in the outbreak

On January 27th, on the third day of the New Year’ Day, Yu Pei, a member and researcher of the Pasteur Institute of the Chinese Academy of Sciences in Shanghai, entered the institute. After unit security took her temperature, they said “Happy New Year” to each other. This is the first face-to-face New Year’s day experienced by Yu Pei in the New Year, when the new coronavirus outbreak spreads.

Scientific commandos in the outbreak

Researchers from the Science and Technology Research Group of the Pasteur Institute in Shanghai of the Chinese Academy of Sciences are working. Supplied by the Pasteur Institute of the Chinese Academy of Sciences in Shanghai

Source: China Science Daily

After that, she walked into the Institute building, and Shanghai Pasteur research backbone together, in the science and technology “Please War Book”, signed their name.

“Please war book” reads: “We are willing to overcome the new coronavirus epidemic at any time to listen to the dispatch, all of our team members are righteous!” “

The Voice of Science and Technology in the Outbreak

Researchers such as Yu Pei were alert edifying the emerging virus on the afternoon of January 12. Just before that, Chinese researchers published a new coronavirus genome sequence in a foreign database. Starting on the afternoon of January 11th, Mr. Zou and the research team began a bioinformatics analysis of the data. After a long night, they finally saw the results on the afternoon of January 12.

“By simulating the structure of the new coronavirus spike protein in Wuhan, it is predicted that the new coronavirus spike protein can bind to the human ACE2 protein, which may infect the epidermal cells of the upper respiratory tract of the human body through this mechanism. “Yu Pei took the data results to consult with the major experts in the field of coronaviruses.

It was agreed that the analytical data in their hands could provide academic reference stos for other researchers, as well as help them understand the origin of the virus, its protozoa, and assess the risk of the virus spreading publicly between species or humans. So they shared the data in time.

With the large output of second-generation sequencing data from viral infection samples, Mr. Zou and others began to consider whether they could share their unknown virus analysis processes to make it easier and more systematic to understand the virus. So, in collaboration with the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences, they established the Virus Genome Automation Identification Cloud Platform (VIC).

“We hope to be able to use the bioinformatics technology we are good at to help hospital institutions make professional judgments quickly. Yu Pei said.

This platform can directly interface with human samples of RNA second-generation sequencing raw data, with fully automated quality control of data, stitching and virus composition analysis and other functions, can be used to comprehensively analyze the patient’s respiratory virus group, study its pathogenic factors, help clinical diagnosis, for the use of appropriate treatment measures to provide reference, It is also possible to monitor the trend of virus variation in order to deploy countermeasures in advance.

Race against time and epidemic

Because of the severity of the outbreak, Yu Pei did not let her research team researchers to work in the institute. “There’s a risk of infection on the way to and from work, and we do bio-information data analysis that can be done from home. Yu Pei said. However, she started on the third day of the new year, working at the institute every day, ready to do various coordination work for the research team.

From the Spring Festival to the present, whether it is to do data analysis, or to establish a “virus genome automation identification cloud platform”, their work has not stopped. Because they know that the outbreak won’t wait for anyone.

Like Yu Pei’s research team, the whole of Shanghai Pasteur is fighting the epidemic and time, because it is a mission embedded in the bones of the institute.

After the SARS outbreak in 2003, the Party Group of the Chinese Academy of Sciences began to organize scientific research forces capable of fighting infectious diseases, and set up a special research institute.

Since its inception, the institute has taken on the mission of fighting the epidemic – focusing on key scientific issues such as the basic life activity of pathogenic microorganisms and the pathogenic mechanism of major infectious diseases, providing scientific and technological support and solutions for public health and biosecurity. For more than a decade, Shanghai Pasteur is ready to rush to the front line of epidemic prevention and control and scientific and technological research when the country and the people need it.

To be a leader in science and technology

“Comrades, this is a battle without smoke, testing the responsibility and responsibility of each party member. “On January 31st, the Party Committee of Shanghai Pasteur called on every Party member and cadre to do a good job in science and technology, leader of epidemic prevention and control, and propagandist of epidemic prevention and control.

Shanghai Pasteur reacted quickly in the battle. Since the outbreak, the Party Committee has studied the spirit of the important instructions of General Secretary Xi Jinping and the decision-making and deployment of the Party Group of the Central Committee and the Chinese Academy of Sciences on the prevention and control of the epidemic and the work of scientific and technological research. On January 23, the Institute established the overall leadership group for the response of the epidemic led by the main leaders of the Party and government and the party committee members led by the science and technology team, the emergency working group, the science and publicity group, and the supply and security group. On January 31st, the Party Committee of the Party carried out a thematic re-study, re-deployment and re-mobilization of the epidemic prevention and control work, and quickly coordinated the formulation of a comprehensive epidemic prevention and control and scientific and technological plan.

The party committee studied the establishment of the scientific and technological commando temporary party branch, by the director, party committee member Tang Hong as branch secretary. The call and deployment of the Institute quickly received a positive response from party members, who rushed to the front line of science and technology from their respective fields of expertise. Under the leadership of the backbone of party research, a series of important work has been completed in a relatively short period of time.

Many Party members and researchers quickly formed a team, in the rapid and sensitive detection, high-efficiency vaccine, neutralizing antibody development in the battle against time, and disease resistance.

Cui Jie, a party member and researcher, led the research group to analyze and speculate on the early evolution mechanism of the new coronavirus of the outbreak, which provides a scientific theoretical basis for identifying the source and transmission of infection and developing an efficient prevention and control strategy as soon as possible.

At the same time, the establishment of virus isolation and detection standard disk, antibody sorting and other work, is also in full swing. Relevant scientific researchers in the Chinese Academy of Sciences under the unified deployment of the Chinese Academy of Sciences Clinical Research Hospital (Hefei) to carry out a comprehensive work.

An outbreak is an order. Today, the outbreak is not over and scientific research is continuing. “Our Party members and comrades will continue to play a pioneering and exemplary role in accordance with the requirements of the organization, rushing ahead and worrying for the Party and the country.” Shanghai Pasteur Party Secretary Shi Victory said.