Virus detection is a key link in the prevention and control of the new coronapneumonia outbreak. The speed of virus detection directly affects the efficiency of a series of work, such as isolation, diagnosis and treatment. Nankai University and a number of domestic universities and related biopharmaceutical enterprises of the scientific research team, successfully developed a new coronavirus (2019-nCoV) IgM / IgG antibody joint testing kit.
The fast test card can be tested in about 15 minutes, with easy operation, easy to interpret, high sensitivity advantages.
Pictured is a new coronavirus diagnostic kit developed by a number of units in the United Nations at Nankai University
This method is expected to break through the existing nucleic acid detection methods on personnel / places of restrictions, shorten the detection time, improve the convenience, promote the diagnosis forward move, to achieve the rapid diagnosis of suspected patients and close contact with the population on-site screening.
After the outbreak of the new coronavirus pneumonia, Nankai University gave full play to the academic advantages of the National Key Laboratory of Pharmaceutical Chemistry Biology in the field of molecular probes in chemical biology, led by Professor Chen Wei, Director of the Key Laboratory, Professor Pang Dewen, and quickly organized a team that included the School of Chemistry, the School of Life Sciences, Joint research team, including experts from the Center for Cross-Science of Cell Responses. They used agglomeration induced luminescence (AIE), quantum dot, colloidal gold and other technologies, and launched a new coronavirus rapid diagnosis technology and its kits. More than a dozen professors in the absence of scientific research assistants, antibodies and reagents in the case of the day after night, lasted 7 days, successfully developed a new coronavirus rapid detection technology.
Among them, Nankai University School of Life Sciences Professor Ding Dan team led, jointly with the Southern Medical University Of southern hospital Professor Zheng Lei team, South China University of Technology Tang Benzhong academician team, Shenzhen Jinjun Biomedical Engineering Co., Ltd. to carry out joint research, successfully developed a new coronavirus IgM / IgG antibody rapid test card.
Pictured is a new coronavirus diagnostic test card developed by a number of units in the United Nations at Nankai University
Researchers said that since the outbreak of new coronary pneumonia, although the ordinary real-time quantitative fluorescence PCR nucleic acid testing played an important role, but by the cumbersome operation, time-consuming and other constraints, but also can not meet the current rapid growth of a large number of suspected patients, asymptomatic infections and other diagnostic testing needs. Antibody detection is an important diagnostic method for viral infections, so the Nankai University team is working on the development of a rapid test card for new coronavirus IgM/IgG antibodies. The successfully developed test card has the advantages of fast test (15 minutes), simple and easy to interpret, and at the same time, the introduction of AIE DOTS/ quantum dot high-performance light-emitting material as a signal unit, greatly improving the sensitivity of antibody detection.
According to reports, the preliminary clinical trial results show that the test card in 40 confirmed new coronary patients in the blood successfully detected antibody-positive 30 cases (75%), of which IgM positive 16 cases (40%), IgG positive 28 cases (70%), in health control and non-new coronary disease sashimi were not detected.
It is understood that since the discovery of a new coronavirus in Wuhan in December 2019, Nankai University has responded positively to the call of the state, assembled in biology, medicine, big data statistics and other disciplines of cutting-edge forces, from vaccine and biological agents research, epidemiological model prediction and other aspects of the epidemic prevention and control research, is progressing smoothly, It is expected to be applied to the first line of epidemic prevention and control as soon as possible.