Yesterday, researchers at the University of Texas at Austin and the National Institutes of Health released their latest findings on the preprint platform bioRxiv for the new 2019 coronavirus. The team said they identified the frozen electron lens structure of the 2019 new coronavirus protrusion protein (S protein) in a pre-converged conformation.
At the same time, it was found that the affinity of the human ACE2 protein with the new coronavirus S protein was 10 to 20 times higher than the affinity combined with the SARS virus S protein.
Then this report was more and more attention, and it was simply thought that the new coronavirus is 10 to 20 times more contagious than SARS, is that really the case?
Huang Bo, deputy director of the Institute of Basic Medicine of the Chinese Academy of Medical Sciences and deputy director of the Department of Immunology of Beijing Concord Medical College, told Science and Technology Daily that the new coronavirus is contagious and relies mainly on S protein to bind to ACE2 protein, and the shape structure of ACE2 subsequently changes, thus mediading the virus into cells. The virus amplifies within the cell, producing more new virus particles, which are released and further infected with normal surrounding cells.
Huang Bo also said that the above-mentioned report results, can only show that the 2019 new coronavirus than SARS virus more easily enter human cells, which may have a relationship with the infection of the virus, but can not conclude that the 2019 new coronavirus is 10 to 20 times the infection of SARS virus.
Finally, Huang also reiterated that while the new 2019 coronavirus has many similarities to the SARS virus, for antibodies, it can be a thousand centimeters, a thousand miles. It cannot be inferred that the vaccine originally used for sars virus can be used in 2019 because the two viruses are similar, and must be tested in rigorous experiments.