A new study from the University of Missouri has once again raised questions about the safety of BPA-free plastics. Bisphenol S (BPS) has almost the same effect on gene expression as BPA, according to an animal research paper published in the Proceedings of the National Academy of Sciences (PNAS). The conclusion is that BPS should be considered as harmful to human health as BPA, and there is still debate about how dangerous such chemicals are.
Bisphenol A and Bisphenol S Molecular (Figure: Wikipedia, via New Atlas)
As a chemical industry, BPA has been widely used in the production of plastics and resins. In the late 1990s, however, scientific research began to question the safety of BPA.
BPA has been the focus of many public health debates over the past decade. A large amount of animal research has been developed to show that BPA can cause endocrine dysfunction, leading to metabolic diseases, and even cancer.
尽管全球不同的卫生机构仍对 BPA 暴露对人体健康的影响存在分歧，但不含 BPA 产品的销量增长，已经直观地表明了公众不愿冒险的想法。
To replace BPA, there are a number of chemicals currently capable of achieving similar effects. Although there are still some unknown costs, many companies only use approximate bpras (such as BPS and BPF).
With this in mind, shopping for items with a BPA-free label does not mean more safety. The new study, for example, at the University of Missouri compared the effects of BPS and BPA on the placenta of developing mice.
Cheryl Rosenfeld says synthetic chemicals such as BPS can penetrate the mother’s placenta, so any substance circulating in the mother’s blood can easily be transferred to the developing fetus.
This mouse model is the best model we can use to simulate the possible effects of BPS during human pregnancy, because the human placenta has a similar structure to the mouse.
The results are striking: BPA and BPS have almost the same effect on animal placentas, with two chemicals altering the expression of the same 13 genes and reducing the concentration of placental serotonin.
The researchers note that these chemicals disrupt the production of placental serotonin, and that lower levels of serotonin can fundamentally alter and impair the development of the fetal brain at critical times.
Exposure to BPA or related alternatives during this period may lead to adverse long-term health consequences. Details of the study have been published in the recent lying journal PNAS, originally titled:
Bisphenol A and Bisphenol S vss of the mouse placenta and the potential effects on the placenta-brain axis