The sudden outbreak, almost disrupted everyone’s 2020 schedule, even if not as exaggerated as the picture on the Internet, all the goals are crossed out, changed to “live” two words, the impact is also huge. Among the disrupted plans, there may be a lot of women’s HPV vaccination programs.
Whether in the country or out to play, may only hit a shot, the back two injections have not fallen, how to do, the vaccine protection is incomplete and what impact?
What The Odd Cake wants to say is, Don’t panic. Scientists at the University of Texas Medical Department recently published an analysis of 130,000 women in the United States, and found that when given the quadved HPV vaccine, the risk of precancerous cancer sickness is basically fairly high.
In other words, the HPV vaccine may be effective in preventing cervical cancer even without a three-shot vaccination process, a strategy that may save a lot of time and money in future cervical cancer prevention and control. The analysis was published in Cancer.
The role of the HPV vaccine is now without doubt, or WHO will not shout the slogan “Eliminate cervical cancer”, but to achieve this goal, it is necessary to ensure that vaccination rates are desirable among those who are suitable for vaccination.
At present, whether it is the second-, fourth-price or nine-price HPV vaccine, the recommended vaccination program is three needles, but the more the number of vaccinations, the more likely there are delays and missed vaccinations for various reasons, affecting the completion rate of vaccination.
So can the HPV vaccination process be shortened from three to two, or even one? Will the protection effect be affected? Various studies are divided, some data say that the change to two shots, the effect of six months apart is better, some still adhere to the existing program, there is really no certainty.
It may not be very good to organize clinical trials directly, so we can only rely on retrospective analysis data. Previous analysis in northern Europe showed that women who had not completed the HPV vaccine had a significantly lower risk of developing cervical cancer precancerous lesions, with cervical endothelial endothelial disease (CIN).
But in that study, only about 20 percent of women didn’t get three shots, and the percentage was less. In this analysis by the University of Texas School of Medicine, the percentage rose to more than 40 percent, and the percentage was even more convincing.
However, from HPV infection, to the emergence of precancerous lesions of cervical cancer, to the actual stage of cervical cancer, is a very long process, HPV vaccine did not appear long, direct evaluation of cancer incidence data is not enough.
Therefore, this study evaluates the protective effect of HPV vaccine, but also the incidence of precancerous lesions, including hetology examination confirmed II/III CIN, cervical cytological examination of the occurrence of high squamous epithelial lesions (HSIL), or can not exclude high-level squamous epithelial lesions atypical squamous epithelial cells (ASC-H).
In the study, the team collected data from more than 60,000 women in the database, more than half of whom were vaccinated after the age of 15, and then compared the data on non-vaccinated women on a 1:1 scale to see how effective the HPV vaccine was.
The results showed that in the ratio of HSIL or ASC-H in cytological examination, 3 doses of vaccine were indeed better protected for women aged 15-19, but the advantages were quite limited, except for the difference between (HR) 0.87 and 0.84. For other age groups, there’s not even an advantage.
In terms of the incidence of II/III CIN, the absolute incidence of 15-19-year-old women who received 1, 2 and 3 doses of vaccine within 5 years was 1.62%, 1.99% and 1.86%, respectively, which was significantly lower than that of non-vaccinated women at 2.65%, and there was no difference between them, and it seemed that 1 or 2 doses of vaccine were really enough.
Anyway, it’s better than not getting a vaccine, can fight or early.
The team said that while cervical cancer prevention is a long-term task that will take longer to reach a definitive conclusion, cancer’s editorial says the “one-shot vaccine is enough” results are emerging and could indeed lead to a change in cervical cancer prevention strategies.
However, The Odd Itycake also stressed that none of these studies can give a definitive conclusion. Female readers who need HPV vaccination should follow the doctor’s instructions to try to complete the immunization process! As for the three shots before the forced home … Wait a minute.