On March 2, local time, wuhan University People’s Hospital scholars published a paper on the preprint website SSRN, said that by reviewing the clinical symptoms of two groups of patients diagnosed at different times in admission, it was found that the clinical symptoms of admission of patients with new coronary pneumonia were changing and generally becoming more hidden. These clues suggest that the new coronavirus may gradually evolve into an influenza-like virus.”
Recent lying patients with fever and other symptoms significantly reduced
The paper is entitled “Note: The clinical characteristics of admission of patients with new coronary pneumonia is changing” (Caution: clinicals of COVID-19 patients are changing at admission), Published on SSRN, a pre-printed website for researchers to share scientific research results, the paper is published by Zhang Wei, deputy director and associate professor of respiratory and critical care medicine at Wuhan University People’s Hospital. It is reported that Zhang Wei has also been involved in the fight against SARS outbreak.
The paper notes that the study sample sedits from 89 confirmed patients with new coronary pneumonia who were admitted between January 16 and January 29. Depending on the time of admission, they were divided into two groups. The first group was 31 patients from 16 to 22 January and the second group was 58 patients from 23 January to 29 January, comparing the differences in clinical symptoms between the two groups.
The study found that only 45.2 per cent of women admitted to hospital before 23 January, compared with 77.6 per cent after 23 January. Patients admitted before 23 January had more systemic symptoms, such as fever, fatigue, muscle aches, etc., but significantly reduced after 23 January. In the case of sputum, 32.3 per cent of patients admitted before 23 January had sputum. After January 23, the proportion of people admitted to hospital with sputum fell to 6.9%.
In addition, 54.2% of patients admitted before 23 January had a decrease in lymphocytes, 52.4% had a decrease in CD3 immune cells, 42.9% had a decrease in CD8 immune cells, and 75% had an increase in SAA, both higher than those admitted after 23 January. The study also noted that there was no significant difference between the two groups of patients with symptoms such as cough, nausea, diarrhea and chest tightness.
New coronavirus ‘settled’ nasopharynx early on unrecognized by body
The researchers say current studies have found that the nasopharyngeal carrier is high shortly after the onset of symptoms. In theory, the nasopharynx was the first organ to be infected with the virus, but observations revealed that the infected groups rarely developupper respiratory symptoms in the early stages of infection. This suggests that the new coronavirus in the nasopharyngeal “settled” is not immediately recognized by the body, and that the body’s immune system is almost unable to remove it by sneezing and runny nose, thus causing the initial symptoms of the new coronavirus to be hidden.
The study compared the clinical symptoms of patients admitted to hospital at different times and found that the initial symptoms of recently infected patients appeared to have become more subtle. “All of this provides clues that the new coronavirus may evolve into a flu-like virus, or may be lurking in some asymptomatic vector for a long time.” “
The researchers caution that even though the initial symptoms of recent infections are more secretive, there is no evidence that the spread and pathogenicity of the new coronavirus decreases in transmission, and that “there is an urgent need to distinguish between clinical performance differences in admissions of patients with neo-coronary pneumonia at different stages of infection due to the emergence of third- and fourth-generation transmission of neo-coronaviruses and even asymptomatic carriers.” “